Carbonate apatite bone replacement: Learn from the bone

研究成果: ジャーナルへの寄稿記事

抄録

Bone is not composed of hydroxyapatite (HAp), but of carbonate apatite (CO3Ap). Although the decomposition of CO3Ap begins at around 400°C, and thus, the fabrication of CO3Ap blocks by sintering is difficult, CO3Ap blocks have recently been fabricated via a dissolutionprecipitation reaction in Na2HPO4 solution using a CaCO3 block as a precursor. Compared to sintered HAp, which is not resorbed by osteoclasts, CO3Ap is resorbed by osteoclasts. Furthermore, CO3Ap upregulates the differentiation of osteoblasts. Therefore, CO3Ap can be used as a replacement for bones with regards to the so-called bone remodeling process. Clinical trials have confirmed the safety and usefulness of CO3Ap granules, including the replacement of CO3Ap granules to new bone. In Dec 2017, CO3Ap was approved as an artificial bone substitute by the Pharmaceuticals and Medical Devices Agency. CO3Ap granules can be used for all dental and maxillofacial surgeries, including the bone reconstruction aimed for dental implantation.

元の言語英語
ページ(範囲)595-601
ページ数7
ジャーナルJournal of the Ceramic Society of Japan
127
発行部数9
DOI
出版物ステータス出版済み - 1 1 2019

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Apatite
apatites
bones
Carbonates
carbonates
Bone
Durapatite
Hydroxyapatite
Bone Substitutes
Osteoblasts
osteoblasts
Surgery
surgery
Sintering
Drug products
carboapatite
implantation
safety
sintering
Decomposition

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry

これを引用

Carbonate apatite bone replacement : Learn from the bone. / Ishikawa, Kunio.

:: Journal of the Ceramic Society of Japan, 巻 127, 番号 9, 01.01.2019, p. 595-601.

研究成果: ジャーナルへの寄稿記事

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