抄録
Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO3Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO3Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 μm). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 15429-15434 |
| ページ数 | 6 |
| ジャーナル | Ceramics International |
| 巻 | 45 |
| 発行部数 | 12 |
| DOI | |
| 出版物ステータス | 出版済み - 8 15 2019 |
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All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Process Chemistry and Technology
- Surfaces, Coatings and Films
- Materials Chemistry
これを引用
Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration. / Hayashi, Koichiro; Munar, Melvin L.; Ishikawa, Kunio.
：: Ceramics International, 巻 45, 番号 12, 15.08.2019, p. 15429-15434.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration
AU - Hayashi, Koichiro
AU - Munar, Melvin L.
AU - Ishikawa, Kunio
PY - 2019/8/15
Y1 - 2019/8/15
N2 - Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO3Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO3Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 μm). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.
AB - Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO3Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO3Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 μm). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.
UR - http://www.scopus.com/inward/record.url?scp=85065522000&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065522000&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2019.05.042
DO - 10.1016/j.ceramint.2019.05.042
M3 - Article
AN - SCOPUS:85065522000
VL - 45
SP - 15429
EP - 15434
JO - Ceramics International
JF - Ceramics International
SN - 0272-8842
IS - 12
ER -