Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration

研究成果: ジャーナルへの寄稿記事

抄録

Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO3Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO3Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 μm). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.

元の言語英語
ページ(範囲)15429-15434
ページ数6
ジャーナルCeramics International
45
発行部数12
DOI
出版物ステータス出版済み - 8 15 2019

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Apatite
Carbonates
Bone
Calcium Carbonate
Calcite
Honeycomb structures
Calcium Hydroxide
Bone Substitutes
Hydrated lime
Grafts
Direction compound
carboapatite
Defects
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

これを引用

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title = "Carbonate apatite granules with uniformly sized pores that arrange regularly and penetrate straight through granules in one direction for bone regeneration",
abstract = "Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO3Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO3Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 μm). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.",
author = "Koichiro Hayashi and Munar, {Melvin L.} and Kunio Ishikawa",
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AU - Hayashi, Koichiro

AU - Munar, Melvin L.

AU - Ishikawa, Kunio

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO3Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO3Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 μm). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.

AB - Artificial bone substitutes that can solve the problems associated with autogenous bone grafts are essential. In this study, macroporous carbonate apatite (CO3Ap) granules with the same composition as natural bone were implanted into distal epiphysis defects in rabbit femurs. Material resorption and bone regeneration were then evaluated. The macroporous granules were obtained by extruding honeycomb (HC) structure rods containing calcium hydroxide, pulverizing the rods to granules, carbonating them to calcite, and converting them from calcite to CO3Ap. Notably, the HC-type macropores fully penetrated and spanned their diameters of the CO3Ap granules in one direction, as well as being regularly arranged and uniformly sized (120 μm). They facilitated cell penetration into the granules and the induction of angiogenesis. As a result, bone remodeling occurred simultaneously within the granules and on the granule surfaces. Furthermore, the granules were gradually resorbed and replaced by bone. Thus, introducing HC-type macropores into granules is an effective approach for promoting bone regeneration.

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