抄録
The effect of carboquone (CQ) on protein synthesis in Chinese hamster V79 cells was determined. While the syntheses of higher molecular weight proteins decreased, the relative level of a 43-kilodalton (kd) protein increased following exposure to CQ at the concentration of 0.5 μg/ml, in a time-related fashion, determined using one-dimensional gel electrophoresis. Using two-dimensional gel electrophoresis, the 43-kd protein may be actin protein, and the syntheses of another two proteins of 8.5/45 and 48/270 (designated isoelectric point/molecular weight, kd) were increased in the CQ-treated V79 cells. These changes of the proteins induced by CQ in V79 cells were noted in HeLa cells. Three CQ-induced proteins are candidates for the elucidation of the antineoplastic effect of CQ.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 253-256 |
| ページ数 | 4 |
| ジャーナル | Oncology |
| 巻 | 44 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 1987 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
これを引用
Carboquone alters the protein synthesis of Chinese hamster V79 cell. / Maehara, Y.; Anai, H.; Kusumoto, H.; Sugimachi, K.
：: Oncology, 巻 44, 番号 4, 01.01.1987, p. 253-256.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Carboquone alters the protein synthesis of Chinese hamster V79 cell
AU - Maehara, Y.
AU - Anai, H.
AU - Kusumoto, H.
AU - Sugimachi, K.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - The effect of carboquone (CQ) on protein synthesis in Chinese hamster V79 cells was determined. While the syntheses of higher molecular weight proteins decreased, the relative level of a 43-kilodalton (kd) protein increased following exposure to CQ at the concentration of 0.5 μg/ml, in a time-related fashion, determined using one-dimensional gel electrophoresis. Using two-dimensional gel electrophoresis, the 43-kd protein may be actin protein, and the syntheses of another two proteins of 8.5/45 and 48/270 (designated isoelectric point/molecular weight, kd) were increased in the CQ-treated V79 cells. These changes of the proteins induced by CQ in V79 cells were noted in HeLa cells. Three CQ-induced proteins are candidates for the elucidation of the antineoplastic effect of CQ.
AB - The effect of carboquone (CQ) on protein synthesis in Chinese hamster V79 cells was determined. While the syntheses of higher molecular weight proteins decreased, the relative level of a 43-kilodalton (kd) protein increased following exposure to CQ at the concentration of 0.5 μg/ml, in a time-related fashion, determined using one-dimensional gel electrophoresis. Using two-dimensional gel electrophoresis, the 43-kd protein may be actin protein, and the syntheses of another two proteins of 8.5/45 and 48/270 (designated isoelectric point/molecular weight, kd) were increased in the CQ-treated V79 cells. These changes of the proteins induced by CQ in V79 cells were noted in HeLa cells. Three CQ-induced proteins are candidates for the elucidation of the antineoplastic effect of CQ.
UR - http://www.scopus.com/inward/record.url?scp=0023274326&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023274326&partnerID=8YFLogxK
U2 - 10.1159/000226489
DO - 10.1159/000226489
M3 - Article
C2 - 3614815
AN - SCOPUS:0023274326
VL - 44
SP - 253
EP - 256
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 4
ER -