抄録
The effect of carboquone (CQ) on protein synthesis in Chinese hamster V79 cells was determined. While the syntheses of higher molecular weight proteins decreased, the relative level of a 43-kilodalton (kd) protein increased following exposure to CQ at the concentration of 0.5 μg/ml, in a time-related fashion, determined using one-dimensional gel electrophoresis. Using two-dimensional gel electrophoresis, the 43-kd protein may be actin protein, and the syntheses of another two proteins of 8.5/45 and 48/270 (designated isoelectric point/molecular weight, kd) were increased in the CQ-treated V79 cells. These changes of the proteins induced by CQ in V79 cells were noted in HeLa cells. Three CQ-induced proteins are candidates for the elucidation of the antineoplastic effect of CQ.
本文言語 | 英語 |
---|---|
ページ(範囲) | 253-256 |
ページ数 | 4 |
ジャーナル | Oncology |
巻 | 44 |
号 | 4 |
DOI | |
出版ステータス | 出版済み - 1987 |
All Science Journal Classification (ASJC) codes
- 腫瘍学
- 癌研究