Carboquone alters the protein synthesis of Chinese hamster V79 cell

Y. Maehara, H. Anai, H. Kusumoto, K. Sugimachi

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

The effect of carboquone (CQ) on protein synthesis in Chinese hamster V79 cells was determined. While the syntheses of higher molecular weight proteins decreased, the relative level of a 43-kilodalton (kd) protein increased following exposure to CQ at the concentration of 0.5 μg/ml, in a time-related fashion, determined using one-dimensional gel electrophoresis. Using two-dimensional gel electrophoresis, the 43-kd protein may be actin protein, and the syntheses of another two proteins of 8.5/45 and 48/270 (designated isoelectric point/molecular weight, kd) were increased in the CQ-treated V79 cells. These changes of the proteins induced by CQ in V79 cells were noted in HeLa cells. Three CQ-induced proteins are candidates for the elucidation of the antineoplastic effect of CQ.

本文言語英語
ページ(範囲)253-256
ページ数4
ジャーナルOncology
44
4
DOI
出版ステータス出版済み - 1 1 1987

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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