TY - JOUR
T1 - Carcinoma of the uterine cervix with variegated histological patterns and calcitonin production
AU - Tsukamoto, Naoki
AU - Hirakawa, Toshio
AU - Matsukuma, Keita
AU - Kaku, Tsunehisa
AU - Matsuyama, Toshitaka
AU - Kamura, Toshiharu
AU - Saito, Toshiaki
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/6
Y1 - 1989/6
N2 - This is a report of a calcitonin-producing cervical cancer with variegated histological patterns. The levels of calcitonin correlated with the clinical course. Multiple lung metastases were completely controlled by cisplatin/Adriamycin/cyclophasphamide combination chemotherapy, although only for a short period. Microscopically, the tumor showed dominant small cell carcinoma; however, it did show differentiation into large cell nonkeratinizing carcinoma, keratinizing carcinoma, adenocarcinoma, and possibly carcinoid. Ultrastructural study revealed a few dense core secretory granules. Multiple immunohistochemical studies were performed. It is presumed that the tumor originated from the totipotent, immature precursor cells in the cervix and differentiated into endocrine carcinoma, squamous cell cancer, and adenocarcinoma.
AB - This is a report of a calcitonin-producing cervical cancer with variegated histological patterns. The levels of calcitonin correlated with the clinical course. Multiple lung metastases were completely controlled by cisplatin/Adriamycin/cyclophasphamide combination chemotherapy, although only for a short period. Microscopically, the tumor showed dominant small cell carcinoma; however, it did show differentiation into large cell nonkeratinizing carcinoma, keratinizing carcinoma, adenocarcinoma, and possibly carcinoid. Ultrastructural study revealed a few dense core secretory granules. Multiple immunohistochemical studies were performed. It is presumed that the tumor originated from the totipotent, immature precursor cells in the cervix and differentiated into endocrine carcinoma, squamous cell cancer, and adenocarcinoma.
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U2 - 10.1016/0090-8258(89)90537-4
DO - 10.1016/0090-8258(89)90537-4
M3 - Article
C2 - 2542143
AN - SCOPUS:0024399973
VL - 33
SP - 395
EP - 399
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 3
ER -
