Cardiac angiotensin II receptors are downregulated by chronic angiotensin II infusion in rats

M. Katoh, K. Egashira, A. Takeshita

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We studied the effect of chronic (7 days) angiotensin II infusion in a subpressor (200 ng/kg per minute) dose on angiotensin II receptors in the left ventricle in rats. Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration. The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20 - 30% in the angiotensin II-infused left ventricular membranes without affecting the affinity. Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

元の言語英語
ページ(範囲)75-77
ページ数3
ジャーナルJapanese Journal of Pharmacology
84
発行部数1
DOI
出版物ステータス出版済み - 10 28 2000
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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