Cardiac angiotensin II receptors are downregulated by chronic angiotensin II infusion in rats

M. Katoh, K. Egashira, A. Takeshita

    研究成果: ジャーナルへの寄稿学術誌査読

    5 被引用数 (Scopus)

    抄録

    We studied the effect of chronic (7 days) angiotensin II infusion in a subpressor (200 ng/kg per minute) dose on angiotensin II receptors in the left ventricle in rats. Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration. The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20 - 30% in the angiotensin II-infused left ventricular membranes without affecting the affinity. Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

    本文言語英語
    ページ(範囲)75-77
    ページ数3
    ジャーナルJapanese Journal of Pharmacology
    84
    1
    DOI
    出版ステータス出版済み - 2000

    !!!All Science Journal Classification (ASJC) codes

    • 薬理学

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