Cardiac structure and function in well-healed burn survivors

T. Jake Samuel, Michael D. Nelson, Aida Nasirian, Manall Jaffery, Gilbert Moralez, Steven A. Romero, Matthew N. Cramer, Mu Huang, Ken Kouda, Michinari Hieda, Satyam Sarma, Craig G. Crandall

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Long-Term burn survivors have reduced aerobic capacity, placing them at increased risk for cardiovascular disease, morbidity, and mortality. However, the exact mechanism contributing to a reduced aerobic capacity remains incompletely understood, but may be related to adverse cardiovascular remodeling. Therefore, it was hypothesized that well-healed burn survivors would exhibit adverse left ventricular (LV) remodeling and impaired LV function. To test this hypothesis, 22 well-healed moderately burned individuals (age: 41 ± 14 years; BMI: 27.7 ± 5.4 kg/m 2; male/female: 12/10; extent of burn: 37 ± 12 %BSA), 11 well-healed severely burned individuals (age: 43 ± 12 years; BMI: 29.5 ± 5.8 kg/m 2; male/female: 8/3; extent of burn: 73 ± 11 %BSA), and 12 healthy, age-matched controls (age: 34 ± 9 years; BMI: 28.6 ± 5.2 kg/m 2; male/female: 5/7) were enrolled in the study. All subjects were sedentary, performing less than 30 minutes of aerobic exercise per day, 3 days per week. LV morphology and function were assessed via cardiac magnetic resonance imaging. In contrast to the hypothesis, neither the presence nor severity of burn injury adversely affected LV morphology or function, when compared with equally sedentary nonburned controls. However, of note, LV mass of all three groups was in the lowest 5th percentile compared with normative values. Finally, group differences in LV morphology were largely explained by differences in aerobic capacity. Taken together, these data suggest a prior burn injury itself does not result in pathological remodeling of the LV and support a role for aerobic exercise training to improve cardiac function.

元の言語英語
ページ(範囲)235-241
ページ数7
ジャーナルJournal of Burn Care and Research
40
発行部数2
DOI
出版物ステータス出版済み - 2 20 2019
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Emergency Medicine
  • Rehabilitation

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    Samuel, T. J., Nelson, M. D., Nasirian, A., Jaffery, M., Moralez, G., Romero, S. A., Cramer, M. N., Huang, M., Kouda, K., Hieda, M., Sarma, S., & Crandall, C. G. (2019). Cardiac structure and function in well-healed burn survivors. Journal of Burn Care and Research, 40(2), 235-241. https://doi.org/10.1093/jbcr/irz008