Cardiovascular protective action of Rho-kinase inhibitors

Yoshitaka Hirooka

    研究成果: Contribution to journalReview article査読

    抄録

    The Rho/Rho-kinase pathway plays an important role in pathophysiology and formation of hypertensive vascular diseases. This pathway contributes to both increased vascular resistance and atherosclerotic changes. The latter includes inflammatory and proliferative changes. In patients with hypertension, inhibition of Rho-kinase has been shown to decrease the increased vascular resistance. Therefore, Rho-kinase will be a new therapeutic target for hypertension and hypertensive vascular diseases. Thus, Rho-kinase inhibitors may have a cardioprotective action.

    本文言語英語
    ページ(範囲)161-171
    ページ数11
    ジャーナルNippon rinsho. Japanese journal of clinical medicine
    62
    1
    出版ステータス出版済み - 1 2004

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

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