Carp thrombocyte phagocytosis requires activation factors secreted from other leukocytes

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

Thrombocytes are nucleated blood cells in non-mammalian vertebrates, which were recently focused on not only as hemostatic cells but also as immune cells with potent phagocytic activities. We have analyzed the phagocytic activation mechanisms in common carp (Cyprinus carpio) thrombocytes. MACS-sorted mAb+ thrombocytes showed no phagocytic activity even in the presence of several stimulants. However, remixing these thrombocytes with other anti-thrombocyte mAb- leukocyte populations restored their phagocytic activities, indicating that carp thrombocyte phagocytosis requires an appropriate exogenous stimulation. Culture supernatant from anti-thrombocyte mAb- leukocytes harvested after PMA or LPS stimulation, but not culture supernatant from unstimulated leukocytes, could activate thrombocyte phagocytosis. This proposed mechanism of thrombocyte phagocytosis activation involving soluble factors produced by activated leukocytes suggests that thrombocyte activation is restricted to areas proximal to injured tissues, ensuring suppression of excessive thrombocyte activation and a balance between inflammation and tissue repair.

本文言語英語
ページ(範囲)107-111
ページ数5
ジャーナルDevelopmental and Comparative Immunology
52
2
DOI
出版ステータス出版済み - 10月 1 2015

!!!All Science Journal Classification (ASJC) codes

  • 免疫学
  • 発生生物学

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