Case of central nervous system inflammatory disease in late pregnancy

Noriko Isobe, Toshikazu Baba, Yuri Nakamura, Koji Shinoda, mitsuru watanabe, Takuya Matsushita, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

抄録

Background: During pregnancy, dynamic changes occur not only in coagulation, but also in immune responses. We report a case of a patient who developed an inflammatory disease in the central nervous system during late pregnancy and was challenging to diagnose. Case presentation: A 27-year-old woman experienced dysarthria during pregnancy at approximately 33 gestational weeks. From the 38th week of pregnancy, she developed general fatigue, clumsiness of the left hand and numbness of the right side of the body. After delivery of her child at 41 weeks’ gestation, she was moved to the neurology ward for further investigation. She showed limb ataxia of the left extremities and sensory disturbance on the right side of the body, including the face. Magnetic resonance imaging detected multiple gadolinium-enhanced lesions at the brainstem and cerebrum. High-dose intravenous methylprednisolone pulse therapy was effective, but her symptoms still remained, including palatal myoclonus. Diagnosing this patient was challenging, but clinically isolated syndrome or multiple sclerosis and neuro-Behҫet's disease were the main candidates. Conclusions: We present a case of a pregnant woman who developed brain inflammatory lesions with unknown etiology. Longitudinal follow up is mandatory for diagnosis with careful tapering of oral prednisolone.

元の言語英語
ページ(範囲)54-58
ページ数5
ジャーナルClinical and Experimental Neuroimmunology
10
発行部数S1
DOI
出版物ステータス出版済み - 3 1 2019

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Central Nervous System Diseases
Pregnancy
Dysarthria
Myoclonus
Hypesthesia
Methylprednisolone
Gadolinium
Cerebrum
Ataxia
Neurology
Prednisolone
Brain Stem
Multiple Sclerosis
Fatigue
Pregnant Women
Extremities
Hand
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Immunology
  • Immunology and Microbiology (miscellaneous)
  • Clinical Neurology

これを引用

Case of central nervous system inflammatory disease in late pregnancy. / Isobe, Noriko; Baba, Toshikazu; Nakamura, Yuri; Shinoda, Koji; watanabe, mitsuru; Matsushita, Takuya; Kira, Jun-Ichi.

:: Clinical and Experimental Neuroimmunology, 巻 10, 番号 S1, 01.03.2019, p. 54-58.

研究成果: ジャーナルへの寄稿記事

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AU - Matsushita, Takuya

AU - Kira, Jun-Ichi

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