Case report: Adjuvant therapy with a high dose of mitotane for adrenocortical carcinoma in a 4-year-old boy

Takako Goto, Kenichi Miyako, Ryuichi Kuromaru, Kenji Ihara, Hiroyuki Torisu, Masafumi Sanefuji, Rie Nagamatsu, Toshiro Hara

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)

抄録

This report concerns control of adrenocortical carcinoma in a 4-yr-old boy by adjuvant mitotane therapy. He presented precocious puberty and was diagnosed with adrenocortical carcinoma. He underwent surgical resection, and adjuvant mitotane therapy was initiated, leading to a final dose of 5.0 g/day. Despite monitoring of the plasma mitotane level, encephalopathy developed 5 mo after initiation. Although he recovered from the encephalopathy, careful follow-up of his growth and development is necessary. On the other hand, he has been free of recurrence and metastases for 3 yr since discontinuation of mitotane. A high dose of mitotane is potentially effective as an adjuvant chemotherapy for adrenocortical carcinoma, although optimal and safe usage needs to be established for children. Copyright

本文言語英語
ページ(範囲)71-74
ページ数4
ジャーナルClinical Pediatric Endocrinology
17
3
DOI
出版ステータス出版済み - 7月 2008

!!!All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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