Ca2+-mediated suppression of the GABA-response through modulation of chloride channel gating in frog sensory neurones

Jan C. Behrends, Tohru Maruyama, Naofumi Tokutomi, Norio Akaike

研究成果: Contribution to journalArticle査読

31 被引用数 (Scopus)

抄録

A suppressant effect of intracelullar free Ca2+ on the γ-aminobutyric acid (GABA)-induced chloride inward current (ICl(GABA)) was studied in isolated frog sensory neurones under whole cell voltage clamp. Voltage-dependent Ca2+ influx elicited during the steady state of ICl(GABA)-induced a fast, slowly recovering current relaxation in the outward direction, the amplitude of which was dependent on total Ca2+ influx. This suppressant effect showed specificity for different divalent actions, suggesting action at a specific intracellular effector. Single channel recording revealed a Ca2+-dependent decrease in the duration of the open time of the GABA-gated Cl- channel without change in single channel conductance.

本文言語英語
ページ(範囲)311-316
ページ数6
ジャーナルNeuroscience Letters
86
3
DOI
出版ステータス出版済み - 4 12 1988

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

フィンガープリント

「Ca<sup>2+</sup>-mediated suppression of the GABA-response through modulation of chloride channel gating in frog sensory neurones」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル