Catalysis by Micelles, Membranes and other Aqueous Aggregates as Models of Enzyme Action

Toyoki Kunitake, Seiji Shinkai

研究成果: Contribution to journalArticle査読

117 被引用数 (Scopus)

抄録

Many biochemical processes proceed in a microheterogeneous system containing organic and aqueous phases. This chapter discusses the structure of various aqueous aggregates. The catalytic action of these aggregates is presented in relation to enzyme catalysis. The underlying theme is the hydrophobic effect. The active site of enzymes is mostly located in a hydrophobic region. Thus, the attachment of enzyme-related functional groups to the hydrophobic core of micelles provides interesting enzyme-model systems. A variety of catalytic groups such as imidazoles and thiols can be enormously activated in a hydrophobic microenvironment. A similar situation exists for coenzyme catalysis. An important area of progress is the enlargement of the scope of the structure of aqueous aggregates. This is highlighted in the chapter.

本文言語英語
ページ(範囲)435-487
ページ数53
ジャーナルAdvances in Physical Organic Chemistry
17
C
DOI
出版ステータス出版済み - 1 1 1980

All Science Journal Classification (ASJC) codes

  • 物理化学および理論化学
  • 有機化学

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