Catalytic asymmetric epoxidation of α-methyl α,β- unsaturated anilides as ester surrogates

Zhihua Chen, Hiroyuki Morimoto, Shigeki Matsunaga, Masakatsu Shibasaki

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抜粋

Catalytic asymmetric epoxidation of α-methyl α,β- unsaturated carboxylic acid derivatives was achieved using anilide as a template. The Pr(Oi-Pr)3-6,6́-Ph-BINOL complex (10 mol%) with a Ph3P(O) (30 mol%) additive promoted the epoxidation of anilides in up to 99% yield and 88% ee. For α-methyl-β-Ph α,β- unsaturated anilide, the Gd(Oi-Pr)3-6,6′-I-BINOL complex (10 mol%) with Ar3P(O) (30 mol%, Ar = 4-methoxyphenyl) was suitable, giving epoxide in 87% yield and 78% ee.

元の言語英語
ページ(範囲)3529-3532
ページ数4
ジャーナルSynlett
発行部数20
DOI
出版物ステータス出版済み - 12 18 2006
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

これを引用