Catalytic asymmetric hydrogenation of N-Boc-imidazoles and oxazoles

Ryoichi Kuwano, Nao Kameyama, Ryuhei Ikeda

研究成果: Contribution to journalArticle査読

73 被引用数 (Scopus)

抄録

Substituted imidazoles and oxazoles were respectively hydrogenated into the corresponding chiral imidazolines and oxazolines (up to 99% ee). The highly enantioselective hydrogenation was achieved by using the chiral ruthenium catalyst, which is generated from Ru(η3-methallyl) 2(cod) and a trans-chelating chiral bisphosphine ligand, PhTRAP. This is the first successful catalytic asymmetric reduction of 5-membered aromatic rings containing two or more heteroatoms.

本文言語英語
ページ(範囲)7312-7315
ページ数4
ジャーナルJournal of the American Chemical Society
133
19
DOI
出版ステータス出版済み - 5 18 2011

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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