Catalytic asymmetric hydrogenation of pyrimidines

Ryoichi Kuwano; Yuta Hashiguchi; Ryuhei Ikeda; Kentaro Ishizuka

doi:10.1002/anie.201410607

Catalytic asymmetric hydrogenation of pyrimidines

Ryoichi Kuwano, Yuta Hashiguchi, Ryuhei Ikeda, Kentaro Ishizuka

複合領域化学

研究成果: Contribution to journal › Article › 査読

34 被引用数 (Scopus)

抄録

The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]₂, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)₃ (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.

本文言語	英語
ページ（範囲）	2393-2396
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	54
号	8
DOI	https://doi.org/10.1002/anie.201410607
出版ステータス	出版済み - 2 16 2015

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

文献へのアクセス

10.1002/anie.201410607

フィンガープリント「Catalytic asymmetric hydrogenation of pyrimidines」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{075badb028b84b09b4282c4195dfd1e3,

title = "Catalytic asymmetric hydrogenation of pyrimidines",

abstract = "The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.",

author = "Ryoichi Kuwano and Yuta Hashiguchi and Ryuhei Ikeda and Kentaro Ishizuka",

year = "2015",

month = feb,

day = "16",

doi = "10.1002/anie.201410607",

language = "English",

volume = "54",

pages = "2393--2396",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "8",

}

TY - JOUR

T1 - Catalytic asymmetric hydrogenation of pyrimidines

AU - Kuwano, Ryoichi

AU - Hashiguchi, Yuta

AU - Ikeda, Ryuhei

AU - Ishizuka, Kentaro

PY - 2015/2/16

Y1 - 2015/2/16

N2 - The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.

AB - The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.

UR - http://www.scopus.com/inward/record.url?scp=85027926634&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85027926634&partnerID=8YFLogxK

U2 - 10.1002/anie.201410607

DO - 10.1002/anie.201410607

M3 - Article

AN - SCOPUS:85027926634

VL - 54

SP - 2393

EP - 2396

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 8

ER -