Catalytic asymmetric hydrogenation of pyrimidines

Ryoichi Kuwano, Yuta Hashiguchi, Ryuhei Ikeda, Kentaro Ishizuka

研究成果: Contribution to journalArticle査読

34 被引用数 (Scopus)

抄録

The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.

本文言語英語
ページ(範囲)2393-2396
ページ数4
ジャーナルAngewandte Chemie - International Edition
54
8
DOI
出版ステータス出版済み - 2 16 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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