抄録
The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 2393-2396 |
| ページ数 | 4 |
| ジャーナル | Angewandte Chemie - International Edition |
| 巻 | 54 |
| 発行部数 | 8 |
| DOI | |
| 出版物ステータス | 出版済み - 2 16 2015 |
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All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
これを引用
Catalytic asymmetric hydrogenation of pyrimidines. / Kuwano, Ryoichi; Hashiguchi, Yuta; Ikeda, Ryuhei; Ishizuka, Kentaro.
：: Angewandte Chemie - International Edition, 巻 54, 番号 8, 16.02.2015, p. 2393-2396.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Catalytic asymmetric hydrogenation of pyrimidines
AU - Kuwano, Ryoichi
AU - Hashiguchi, Yuta
AU - Ikeda, Ryuhei
AU - Ishizuka, Kentaro
PY - 2015/2/16
Y1 - 2015/2/16
N2 - The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.
AB - The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.
UR - http://www.scopus.com/inward/record.url?scp=85027926634&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027926634&partnerID=8YFLogxK
U2 - 10.1002/anie.201410607
DO - 10.1002/anie.201410607
M3 - Article
AN - SCOPUS:85027926634
VL - 54
SP - 2393
EP - 2396
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 8
ER -