Catalytic chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester: Hydroxy group over amino group and conjugate addition over transesterification

Zhao Li, Masamichi Tamura, Ryo Yazaki, Takashi Ohshima

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抜粋

A highly chemoselective conjugate addition of amino alcohols to α,β-unsaturated ester using a soft Lewis acid/hard Brønsted base cooperative catalyst was developed. This catalysis achieved chemoselective addition of a hydroxy group over an amino group. Moreover, soft metal alkoxide generation enabled chemoselective soft conjugate addition over hard transesterification. Various amino alcohols, including unprecedented cyclic β-amino alcohol, were applicable to the present catalysis.

元の言語英語
ページ(範囲)19-21
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
65
発行部数1
DOI
出版物ステータス出版済み - 1 1 2017

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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