@article{7e95676b9ec641bd9e077979bcd6a3fa,
title = "Catalytic Dehydrogenative β-Alkylation of Amino Acid Schiff Bases with Hydrocarbon",
abstract = "A synthetic method for the synthesis of a highly congested α,β-dehydroamino acid through the β-C–H bond activation of an amino acid Schiff base is described. Abundant hydrocarbon feedstock could be used as an alkylating reagent to afford an α,β-dehydroamino acid bearing a quaternary carbon at the γ-position with an exclusively (Z)-geometry. Notably, a tetrasubstituted olefin could be constructed from saturated starting materials. The transformation of the synthesized α,β-dehydroamino acid into unnatural α-amino acid derivatives was also demonstrated.",
author = "Tetsu Ikeda and Haruka Ochiishi and Mana Yoshida and Ryo Yazaki and Takashi Ohshima",
note = "Funding Information: This work was financially supported by JSPS KAKENHI Grants JP15H05846 in Middle Molecular Strategy and JP18H04263 in Precisely Designed Catalysts with Customized Scaffolding, a Grant-in-Aid for Scientific Research (B) (no. 21H02607), a Grant-in-Aid for Challenging Research (Exploratory) (no. 19K22501), Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) (JP20am0101091), and JP21ak0101167 from AMED. R.Y. thanks the Takeda Science Foundation, Noguchi Institute, and Astellas Foundation for Research on Metabolic Disorders for financial support. Publisher Copyright: {\textcopyright} 2021 American Chemical Society",
year = "2022",
month = jan,
day = "14",
doi = "10.1021/acs.orglett.1c04042",
language = "English",
volume = "24",
pages = "369--373",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "1",
}