Cbx2, a polycomb group gene, is required for Sry gene expression in mice

Yuko Katoh-Fukui, Kanako Miyabayashi, Tomoko Komatsu, Akiko Owaki, Takashi Baba, Yuichi Shima, Tomohide Kidokoro, Yoshiakira Kanai, Andreas Schedl, Dagmar Wilhelm, Peter Koopman, Yasushi Okuno, Ken Ichirou Morohashi

研究成果: ジャーナルへの寄稿学術誌査読

105 被引用数 (Scopus)


Mice lacking the function of the polycomb group protein CBX2 (chromobox homolog 2; also known as M33) show defects in gonadal, adrenal, and splenic development. In particular, XY knockout (KO) mice develop ovaries but not testes, and the gonads are hypoplastic in both sexes. However, how CBX2 regulates development of these tissues remains largely unknown. In the present study, weused microarray, RT-PCR, and immunohistochemical analyses to show that the expression of Sry, Sox9, Lhx9, Ad4BP/SF-1, Dax-1, Gata4, Arx, and Dmrt1, genes encoding transcription factors essential for gonadal development, is affected in Cbx2 KO gonads. Male-to-female sex reversal in Cbx2 KO mice was rescued by crossing them with transgenic mice displaying forced expression of Sry or Sox9. However, testes remained hypoplastic in these mice, indicating that the size and the sex of the gonad are determined by different sets of genes. Our study implicates Cbx2 in testis differentiation through regulating Sry gene expression.

出版ステータス出版済み - 2月 2012

!!!All Science Journal Classification (ASJC) codes

  • 内分泌学


「Cbx2, a polycomb group gene, is required for Sry gene expression in mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。