CD24 modulates chemosensitivity of MCF-7 breast cancer cells

Hideya Ohnishi, Kumi Suyama, Akio Yamasaki, Yasuhiro Oyama, Akiko Fujimura, Makoto Kawamoto, Akira Imaizumi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

The role of cluster of differentiation (CD) 24 in breast cancer remains unclear; previously, we showed that CD24 suppresses malignant phenotypes by inactivating Hedgehog signaling through signal transducer and activator of transcription (STAT) 1 inhibition. In this study, we examined how CD24 affects chemosensitivity in breast cancer cells. The CD44+CD24+ breast cancer cell line MCF-7 was transfected with CD24 with/without STAT1 siRNA, and chemosensitivity to 5-fluorouracil (5-FU) and cis-diamminedichloroplatinum (CDDP) was measured. CD24 inhibition reduced chemosensitivity to 5-FU, while STAT1 inhibition did not affect chemosensitivity to 5-FU in CD24 siRNA-transfected cells. Conversely, CD24 inhibition did not affect chemosensitivity to CDDP, while STAT1 inhibition reduced chemosensitivity to CDDP in CD24 siRNA-transfected cells. STAT1 inhibition, but not CD24 inhibition, reduced expression of the ATP-binding cassette (ABC) transporter genes, ABCB1 and ABCG2. In conclusion, CD24 inhibition may modulate chemosensitivity according to drug type, but ABC transporter expression appears not to contribute to this mechanism. This study contributes to determining the role of CD24 in breast cancer.

元の言語英語
ページ(範囲)561-566
ページ数6
ジャーナルAnticancer Research
37
発行部数2
DOI
出版物ステータス出版済み - 1 1 2017

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Fluorouracil
Breast Neoplasms
Small Interfering RNA
Cisplatin
ATP-Binding Cassette Transporters
STAT1 Transcription Factor
Phenotype
Cell Line
Pharmaceutical Preparations
Genes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Ohnishi, H., Suyama, K., Yamasaki, A., Oyama, Y., Fujimura, A., Kawamoto, M., & Imaizumi, A. (2017). CD24 modulates chemosensitivity of MCF-7 breast cancer cells. Anticancer Research, 37(2), 561-566. https://doi.org/10.21873/anticanres.11349

CD24 modulates chemosensitivity of MCF-7 breast cancer cells. / Ohnishi, Hideya; Suyama, Kumi; Yamasaki, Akio; Oyama, Yasuhiro; Fujimura, Akiko; Kawamoto, Makoto; Imaizumi, Akira.

:: Anticancer Research, 巻 37, 番号 2, 01.01.2017, p. 561-566.

研究成果: ジャーナルへの寄稿記事

Ohnishi, H, Suyama, K, Yamasaki, A, Oyama, Y, Fujimura, A, Kawamoto, M & Imaizumi, A 2017, 'CD24 modulates chemosensitivity of MCF-7 breast cancer cells', Anticancer Research, 巻. 37, 番号 2, pp. 561-566. https://doi.org/10.21873/anticanres.11349
Ohnishi H, Suyama K, Yamasaki A, Oyama Y, Fujimura A, Kawamoto M その他. CD24 modulates chemosensitivity of MCF-7 breast cancer cells. Anticancer Research. 2017 1 1;37(2):561-566. https://doi.org/10.21873/anticanres.11349
Ohnishi, Hideya ; Suyama, Kumi ; Yamasaki, Akio ; Oyama, Yasuhiro ; Fujimura, Akiko ; Kawamoto, Makoto ; Imaizumi, Akira. / CD24 modulates chemosensitivity of MCF-7 breast cancer cells. :: Anticancer Research. 2017 ; 巻 37, 番号 2. pp. 561-566.
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