CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease

Shinichi Somada, Hiromi Muta, Kazuhiko Nakamura, Xun Sun, Kuniomi Honda, Eikichi Ihara, Hirotada Akiho, Ryoichi Takayanagi, Yasunobu Yoshikai, Eckhard R. Podack, Kenzaburo Tani

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Background and Aims Although CD30 has long been recognized as an important marker in many lymphomas of diverse origin, and as an activation molecule on B and T cells, its primary function has remained obscure. Soluble CD30 (sCD30) is released from CD30 on the cell membrane by enzymatic cleavage. This study investigated the role of CD30 ligand (CD30L)/CD30 signals in intestinal mucosal damage. Methods Serum sCD30 in patients with ulcerative colitis (UC) and Crohn's disease (CD) and healthy individuals was assessed. A model of enteritis induced by anti-CD3 monoclonal antibody injection was studied in wild-type mice and in CD30L knockout mice. Results Increased sCD30 was observed in UC and CD patients, and the level was correlated with disease activity in both conditions. In a murine model of enteritis, histological intestinal damage was significantly reduced in CD30L knockout mice with decreased Th1 and Th17 cytokine levels. Moreover, blocking of CD30L/CD30 signals by CD30-immunoglobulin (CD30-Ig) resulted in reduced inflammation. Conclusions Increased sCD30 expression correlating with disease activity suggested that CD30L/CD30 signals play an important role in pathogenesis of UC and CD. CD30L/CD30 pathway acts as an accelerator of enteritis in a murine disease model. Successful blockade of enteritis by CD30-Ig suggests a potential tool for future therapy of inflammatory bowel diseases.

元の言語英語
ページ(範囲)2031-2037
ページ数7
ジャーナルDigestive Diseases and Sciences
57
発行部数8
DOI
出版物ステータス出版済み - 8 1 2012

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CD30 Ligand
Inflammatory Bowel Diseases
Enteritis
Ulcerative Colitis
Crohn Disease
Knockout Mice
Immunoglobulins
Lymphoma
B-Lymphocytes
Monoclonal Antibodies
Cell Membrane
Cytokines
Inflammation
T-Lymphocytes
Injections

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Physiology

これを引用

CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease. / Somada, Shinichi; Muta, Hiromi; Nakamura, Kazuhiko; Sun, Xun; Honda, Kuniomi; Ihara, Eikichi; Akiho, Hirotada; Takayanagi, Ryoichi; Yoshikai, Yasunobu; Podack, Eckhard R.; Tani, Kenzaburo.

:: Digestive Diseases and Sciences, 巻 57, 番号 8, 01.08.2012, p. 2031-2037.

研究成果: ジャーナルへの寄稿記事

Somada, S, Muta, H, Nakamura, K, Sun, X, Honda, K, Ihara, E, Akiho, H, Takayanagi, R, Yoshikai, Y, Podack, ER & Tani, K 2012, 'CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease', Digestive Diseases and Sciences, 巻. 57, 番号 8, pp. 2031-2037. https://doi.org/10.1007/s10620-012-2129-0
Somada, Shinichi ; Muta, Hiromi ; Nakamura, Kazuhiko ; Sun, Xun ; Honda, Kuniomi ; Ihara, Eikichi ; Akiho, Hirotada ; Takayanagi, Ryoichi ; Yoshikai, Yasunobu ; Podack, Eckhard R. ; Tani, Kenzaburo. / CD30 ligand/CD30 interaction is involved in pathogenesis of inflammatory bowel disease. :: Digestive Diseases and Sciences. 2012 ; 巻 57, 番号 8. pp. 2031-2037.
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AU - Muta, Hiromi

AU - Nakamura, Kazuhiko

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AU - Honda, Kuniomi

AU - Ihara, Eikichi

AU - Akiho, Hirotada

AU - Takayanagi, Ryoichi

AU - Yoshikai, Yasunobu

AU - Podack, Eckhard R.

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