CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model

Tomohiro Matsumoto, Shiro Imagama, Kenichi Hirano, Tomohiro Ohgomori, Takamitsu Natori, Kazuyoshi Kobayashi, Akio Muramoto, Naoki Ishiguro, Kenji Kadomatsu

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

抄録

Amyotrophic lateral sclerosis (ALS) is a motor neuron-specific neurodegenerative disease. An increasing body of evidence suggests that, in addition to cell autonomous regulation, i.e., pathological changes in motor neurons, non-cell autonomous mechanisms involving glial cells play critical roles in the pathogenesis of ALS. CD44 functions as a receptor for osteopontin and hyaluronan, and has been implicated in inflammation associated with neuronal injuries. However, this membrane glycoprotein has been poorly studied in ALS. Here we investigated its expression during ALS progression using SOD1 G93A mice. CD44 expression increased around the onset of disease and then increased continuously. Astrocytes and microglia expressed CD44 in vivo. Consistent with these findings, primary cultured microglia began to express CD44 upon activation with LPS and interferon-γ. CD44 expression in primary cultured astrocytes was also enhanced by activation with interferon-γ+TNF-α or bFGF alone. As CD44 was detected in cell lysate, but not in culture media of astrocytes and microglia, it was likely that these glial cells expressed a membrane-bound form of CD44. Our study demonstrates that CD44 expression in astrocytes and microglia is closely associated with the pathogenesis of ALS, and suggests that inflammatory responses involving CD44 may play a role in this disease.

元の言語英語
ページ(範囲)115-120
ページ数6
ジャーナルNeuroscience Letters
520
発行部数1
DOI
出版物ステータス出版済み - 6 27 2012
外部発表Yes

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Amyotrophic Lateral Sclerosis
Microglia
Astrocytes
Motor Neurons
Neuroglia
Interferons
CD44 Antigens
Osteopontin
Membrane Glycoproteins
Neurodegenerative Diseases
Culture Media
Inflammation
Membranes
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model. / Matsumoto, Tomohiro; Imagama, Shiro; Hirano, Kenichi; Ohgomori, Tomohiro; Natori, Takamitsu; Kobayashi, Kazuyoshi; Muramoto, Akio; Ishiguro, Naoki; Kadomatsu, Kenji.

:: Neuroscience Letters, 巻 520, 番号 1, 27.06.2012, p. 115-120.

研究成果: ジャーナルへの寄稿記事

Matsumoto, T, Imagama, S, Hirano, K, Ohgomori, T, Natori, T, Kobayashi, K, Muramoto, A, Ishiguro, N & Kadomatsu, K 2012, 'CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model', Neuroscience Letters, 巻. 520, 番号 1, pp. 115-120. https://doi.org/10.1016/j.neulet.2012.05.048
Matsumoto, Tomohiro ; Imagama, Shiro ; Hirano, Kenichi ; Ohgomori, Tomohiro ; Natori, Takamitsu ; Kobayashi, Kazuyoshi ; Muramoto, Akio ; Ishiguro, Naoki ; Kadomatsu, Kenji. / CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model. :: Neuroscience Letters. 2012 ; 巻 520, 番号 1. pp. 115-120.
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AU - Muramoto, Akio

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