CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

Xuefang Ren, Kozaburo Akiyoshi, Arthur A. Vandenbark, Patricia D. Hurn, Halina Offner

研究成果: Contribution to journalArticle査読

83 被引用数 (Scopus)

抄録

Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4+CD25 +Foxp3+ regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3DTR mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage.

本文言語英語
ページ(範囲)87-90
ページ数4
ジャーナルMetabolic Brain Disease
26
1
DOI
出版ステータス出版済み - 3 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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