Cdh1 is an antagonist of the spindle assembly checkpoint

Masayoshi Nagai, Takashi Ushimaru

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

The spindle assembly checkpoint (SAC) monitors unsatisfied connections of microtubules to kinetochores and prevents anaphase onset by inhibition of the ubiquitin ligase E3 anaphase-promoting complex or cyclosome (APC/C) in association with the activator Cdc20. Another APC/C activator, Cdh1, exists permanently throughout the cell cycle but it becomes active from telophase to G1. Here, we show that Cdh1 is partially active and mediates securin degradation even in SAC-active metaphase cells. Additionally, Cdh1 mediates Cdc20 degradation in metaphase, promoting formation of the APC/C-Cdh1. These results indicate that Cdh1 opposes the SAC and promotes anaphase transition.

本文言語英語
ページ(範囲)2217-2222
ページ数6
ジャーナルCellular Signalling
26
10
DOI
出版ステータス出版済み - 10 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 細胞生物学

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