C/EBPΑ is required for development of dendritic cell progenitors

Robert S. Welner, Deepak Bararia, Giovanni Amabile, Akos Czibere, Touati Benoukraf, Christian Bach, K. Disnika Senali Abayratna Wansa, Min Ye, Hong Zhang, Tadafumi Iino, Christopher J. Hetherington, Koichi Akashi, Daniel G. Tenen

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抜粋

Dendritic cells (DCs) are master regulators of the immune system, but molecular regulation of early DC differentiation has been poorly understood. Here, we report that the transcription factor C/EBPa coordinates the development of progenitor cells required for production of multiple categories of DCs. C/EBPa was needed for differentiation from stem/progenitor cells to common DC progenitors (CDPs), but not for transition of CDP to mature DCs. C/EBPa deletion in mature DCs did not affect their numbers or function, suggesting that this transcription factor is not needed for maintenance of DCs in lymphoid tissues. ChIP-seq and microarrays were used to identify candidate genes regulated by C/EBPa and required for DC formation. Genes previously shown to be critical for DC formation were bound by C/EBPa, and their expression was decreased in the earliest hematopoietic compartments in the absence of C/EBPa. These data indicate that C/EBPa is important for the earliest stages of steady-state DC differentiation.

元の言語英語
ページ(範囲)4073-4081
ページ数9
ジャーナルBlood
121
発行部数20
DOI
出版物ステータス出版済み - 5 16 2013

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

これを引用

Welner, R. S., Bararia, D., Amabile, G., Czibere, A., Benoukraf, T., Bach, C., ... Tenen, D. G. (2013). C/EBPΑ is required for development of dendritic cell progenitors. Blood, 121(20), 4073-4081. https://doi.org/10.1182/blood-2012-10-463448