C/EBPΑ is required for development of dendritic cell progenitors

Robert S. Welner, Deepak Bararia, Giovanni Amabile, Akos Czibere, Touati Benoukraf, Christian Bach, K. Disnika Senali Abayratna Wansa, Min Ye, Hong Zhang, Tadafumi Iino, Christopher J. Hetherington, Koichi Akashi, Daniel G. Tenen

研究成果: ジャーナルへの寄稿学術誌査読

21 被引用数 (Scopus)


Dendritic cells (DCs) are master regulators of the immune system, but molecular regulation of early DC differentiation has been poorly understood. Here, we report that the transcription factor C/EBPa coordinates the development of progenitor cells required for production of multiple categories of DCs. C/EBPa was needed for differentiation from stem/progenitor cells to common DC progenitors (CDPs), but not for transition of CDP to mature DCs. C/EBPa deletion in mature DCs did not affect their numbers or function, suggesting that this transcription factor is not needed for maintenance of DCs in lymphoid tissues. ChIP-seq and microarrays were used to identify candidate genes regulated by C/EBPa and required for DC formation. Genes previously shown to be critical for DC formation were bound by C/EBPa, and their expression was decreased in the earliest hematopoietic compartments in the absence of C/EBPa. These data indicate that C/EBPa is important for the earliest stages of steady-state DC differentiation.

出版ステータス出版済み - 5月 16 2013

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学


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