C/EBPβ is required for 'emergency' granulopoiesis

Hideyo Hirai, Pu Zhang, Tajhal Dayaram, Christopher J. Hetherington, Shin Ichi Mizuno, Jiro Imanishi, Koichi Akashi, Daniel G. Tenen

研究成果: Contribution to journalArticle査読

280 被引用数 (Scopus)

抄録

During 'emergency' situations such as infections, host defense requires rapid mobilization of bone marrow granulocyte progenitors. 'Steady-state' granulopoiesis is absolutely dependent on the C/EBPα transcription factor, but the transcriptional mechanisms underlying emergency granulopoiesis remain unclear. Here we show that large numbers of granulocytes were generated from C/EBPα-deficient progenitors after cytokine stimulation in vivo. Cytokine treatment or fungal infection induced upregulation of C/EBPβ but not C/EBPα or C/EBPε transcripts in granulocyte progenitors, and C/EBPβ-deficient progenitors showed decreased emergency-induced granulopoiesis in vitro and in vivo. C/EBPβ inhibited proliferation less severely than did C/EBPα. These data suggest a critical function for C/EBPβ in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors.

本文言語英語
ページ(範囲)732-739
ページ数8
ジャーナルNature Immunology
7
7
DOI
出版ステータス出版済み - 7 2006

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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