Cell adhesion on glassy scaffolds with a different mechanical response

Shinichiro Shimomura, Hisao Matsuno, Kazuaki Sanada, Keiji Tanaka

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

L929 mouse fibroblast cells were cultured on bilayer films composed of a glassy poly(methyl methacrylate) (PMMA) on a rubbery polyisoprene. When the thickness of the upper PMMA film fell short of a threshold value of 50 nm, the adhesion of fibroblasts on it was remarkably suppressed. A possible explanation is that the surface of a bilayer with an ultrathin PMMA layer apparently becomes softer due to the manifestation of a mechanical response from the rubbery layer underneath. Finite element analysis shows that the shear stress at the bilayer surface induced by traction force of the attached cells is dependent on the PMMA thickness, similar to the cell adhesion behavior. These results make it clear that fibroblasts can sense the surface stiffness of polymers with a modulus even on the order of MPa.

元の言語英語
ページ(範囲)714-719
ページ数6
ジャーナルJournal of Materials Chemistry B
5
発行部数4
DOI
出版物ステータス出版済み - 1 1 2017

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Cell adhesion
Polymethyl Methacrylate
Scaffolds (biology)
Polymethyl methacrylates
Fibroblasts
Polyisoprenes
Shear stress
Polymers
Adhesion
Cells
Stiffness
Finite element method

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

これを引用

Cell adhesion on glassy scaffolds with a different mechanical response. / Shimomura, Shinichiro; Matsuno, Hisao; Sanada, Kazuaki; Tanaka, Keiji.

:: Journal of Materials Chemistry B, 巻 5, 番号 4, 01.01.2017, p. 714-719.

研究成果: ジャーナルへの寄稿記事

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