Cell Adhesion Structures in Epithelial Cells Are Formed in Dynamic and Cooperative Ways

Kenta Shigetomi, Junichi Ikenouchi

研究成果: ジャーナルへの寄稿評論記事

抄録

There are many morphologically distinct membrane structures with different functions at the surface of epithelial cells. Among these, adherens junctions (AJ) and tight junctions (TJ) are responsible for the mechanical linkage of epithelial cells and epithelial barrier function, respectively. In the process of new cell–cell adhesion formation between two epithelial cells, such as after wounding, AJ form first and then TJ form on the apical side of AJ. This process is very complicated because AJ formation triggers drastic changes in the organization of actin cytoskeleton, the activity of Rho family of small GTPases, and the lipid composition of the plasma membrane, all of which are required for subsequent TJ formation. In this review, the authors focus on the relationship between AJ and TJ as a representative example of specialization of plasma membrane regions and introduce recent findings on how AJ formation promotes the subsequent formation of TJ.

元の言語英語
記事番号1800227
ジャーナルBioEssays
41
発行部数7
DOI
出版物ステータス出版済み - 7 1 2019

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Adherens Junctions
Cell adhesion
Cell Adhesion
Tight Junctions
Epithelial Cells
Cell membranes
Membrane structures
Monomeric GTP-Binding Proteins
Actins
Adhesion
Cell Membrane
Lipids
Chemical analysis
Actin Cytoskeleton
Membranes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Cell Adhesion Structures in Epithelial Cells Are Formed in Dynamic and Cooperative Ways. / Shigetomi, Kenta; Ikenouchi, Junichi.

:: BioEssays, 巻 41, 番号 7, 1800227, 01.07.2019.

研究成果: ジャーナルへの寄稿評論記事

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abstract = "There are many morphologically distinct membrane structures with different functions at the surface of epithelial cells. Among these, adherens junctions (AJ) and tight junctions (TJ) are responsible for the mechanical linkage of epithelial cells and epithelial barrier function, respectively. In the process of new cell–cell adhesion formation between two epithelial cells, such as after wounding, AJ form first and then TJ form on the apical side of AJ. This process is very complicated because AJ formation triggers drastic changes in the organization of actin cytoskeleton, the activity of Rho family of small GTPases, and the lipid composition of the plasma membrane, all of which are required for subsequent TJ formation. In this review, the authors focus on the relationship between AJ and TJ as a representative example of specialization of plasma membrane regions and introduce recent findings on how AJ formation promotes the subsequent formation of TJ.",
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