Cell death or survival against oxidative stress

Non Miyata, Kanji Okumoto, Yukio Fujiki

研究成果: 著書/レポートタイプへの貢献

抄録

Peroxisomes contain anabolic and catabolic enzymes including oxidases that produce hydrogen peroxide as a by-product. Peroxisomes also contain catalase to metabolize hydrogen peroxide. It has been recognized that catalase is localized to cytosol in addition to peroxisomes. A recent study has revealed that loss of VDAC2 shifts localization of BAK, a pro-apoptotic member of Bcl-2 family, from mitochondria to peroxisomes and cytosol, thereby leading to release of peroxisomal matrix proteins including catalase to the cytosol. A subset of BAK is localized to peroxisomes even in wild-type cells, regulating peroxisomal membrane permeability and catalase localization. The cytosolic catalase potentially acts as an antioxidant to eliminate extra-peroxisomal hydrogen peroxide.

元の言語英語
ホスト出版物のタイトルSubcellular Biochemistry
出版者Springer New York
ページ463-471
ページ数9
DOI
出版物ステータス出版済み - 1 1 2018

出版物シリーズ

名前Subcellular Biochemistry
89
ISSN(印刷物)0306-0225

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Peroxisomes
Oxidative stress
Cell death
Catalase
Cell Survival
Oxidative Stress
Cell Death
Cytosol
Hydrogen Peroxide
Mitochondria
Byproducts
Permeability
Oxidoreductases
Antioxidants
Membranes
Enzymes
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

これを引用

Miyata, N., Okumoto, K., & Fujiki, Y. (2018). Cell death or survival against oxidative stress. : Subcellular Biochemistry (pp. 463-471). (Subcellular Biochemistry; 巻数 89). Springer New York. https://doi.org/10.1007/978-981-13-2233-4_20

Cell death or survival against oxidative stress. / Miyata, Non; Okumoto, Kanji; Fujiki, Yukio.

Subcellular Biochemistry. Springer New York, 2018. p. 463-471 (Subcellular Biochemistry; 巻 89).

研究成果: 著書/レポートタイプへの貢献

Miyata, N, Okumoto, K & Fujiki, Y 2018, Cell death or survival against oxidative stress. : Subcellular Biochemistry. Subcellular Biochemistry, 巻. 89, Springer New York, pp. 463-471. https://doi.org/10.1007/978-981-13-2233-4_20
Miyata N, Okumoto K, Fujiki Y. Cell death or survival against oxidative stress. : Subcellular Biochemistry. Springer New York. 2018. p. 463-471. (Subcellular Biochemistry). https://doi.org/10.1007/978-981-13-2233-4_20
Miyata, Non ; Okumoto, Kanji ; Fujiki, Yukio. / Cell death or survival against oxidative stress. Subcellular Biochemistry. Springer New York, 2018. pp. 463-471 (Subcellular Biochemistry).
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