TY - GEN
T1 - Cell deformability measurements for single cancer cells by ionic current in microfluidic devices
AU - Sano, Mamiko
AU - Kaji, Noritada
AU - Yasui, Takao
AU - Baba, Yoshinobu
N1 - Funding Information:
This work was partly supported the Nanotechnology Platform Program (Molecule and Material Synthesis) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), the JSPS Grant-in-Aid for Scientific Research (A) 24241050.
Publisher Copyright:
© 15CBMS-0001.
PY - 2015
Y1 - 2015
N2 - To realize high-throughput, easy to use, and high-accuracy cell deformability measurements, we have developed ionic current detection system combined with constriction structure inside microchannel. In this system, when cells are clogged in constriction, the resistivity of detection area increases and the current decreases by ionic current blockade. We successfully detected unique signal shapes derived from cell deformability during the cell passage at the constriction. The signal shapes might provide an information on cell deformation and nucleus position inside a cell.
AB - To realize high-throughput, easy to use, and high-accuracy cell deformability measurements, we have developed ionic current detection system combined with constriction structure inside microchannel. In this system, when cells are clogged in constriction, the resistivity of detection area increases and the current decreases by ionic current blockade. We successfully detected unique signal shapes derived from cell deformability during the cell passage at the constriction. The signal shapes might provide an information on cell deformation and nucleus position inside a cell.
UR - http://www.scopus.com/inward/record.url?scp=84983292952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983292952&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84983292952
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 455
EP - 457
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -
