Cell kinetics of the malignant evolution of meningothelial meningioma

T. Iwaki, I. Takeshita, M. Fukui, K. Kitamura

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

A meningotheliomatous meningioma occurred in the right parietal parasagittal region of a 43-year-old woman. A total excision was carried out. Three years and 9 months later, one parasagittal and two falx tumours in close proximity recurred and were excised. The falx tumors showed the features of an anaplastic transitional meningioma with increased mitoses. The falx meningioma recurred locally and repeatedly, despite radiation therapy and chemoimmunotherapy. She died 7 years and 8 months after the onset. At autopsy, the tumor was found to have metastasized via the cerebrospinal fluid to the spinal cord and pituitary stalk. Extracranial metastases were not evident. At the fourth craniotomy, bromodeoxyuridine (BrdU) was administered intravenously to label tumor cells in the S phase of the cell cycle. The BrdU-labeled cells accounted for 9.0%; they are usually less than 1% in benign meningiomas. Meningothelial meningiomas with a high labeling index recur rapidly, even after Simpson's grade 2 removal, and treatment for a malignant meningioma should be instituted.

元の言語英語
ページ(範囲)243-247
ページ数5
ジャーナルActa neuropathologica
74
発行部数3
DOI
出版物ステータス出版済み - 9 1 1987

Fingerprint

Meningioma
Bromodeoxyuridine
Neoplasms
Parietal Lobe
Craniotomy
Pituitary Gland
S Phase
Mitosis
Cerebrospinal Fluid
Autopsy
Spinal Cord
Cell Cycle
Radiotherapy
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

これを引用

Cell kinetics of the malignant evolution of meningothelial meningioma. / Iwaki, T.; Takeshita, I.; Fukui, M.; Kitamura, K.

:: Acta neuropathologica, 巻 74, 番号 3, 01.09.1987, p. 243-247.

研究成果: ジャーナルへの寄稿記事

Iwaki, T. ; Takeshita, I. ; Fukui, M. ; Kitamura, K. / Cell kinetics of the malignant evolution of meningothelial meningioma. :: Acta neuropathologica. 1987 ; 巻 74, 番号 3. pp. 243-247.
@article{ff6e0217284b4172a203c57d7173b8cb,
title = "Cell kinetics of the malignant evolution of meningothelial meningioma",
abstract = "A meningotheliomatous meningioma occurred in the right parietal parasagittal region of a 43-year-old woman. A total excision was carried out. Three years and 9 months later, one parasagittal and two falx tumours in close proximity recurred and were excised. The falx tumors showed the features of an anaplastic transitional meningioma with increased mitoses. The falx meningioma recurred locally and repeatedly, despite radiation therapy and chemoimmunotherapy. She died 7 years and 8 months after the onset. At autopsy, the tumor was found to have metastasized via the cerebrospinal fluid to the spinal cord and pituitary stalk. Extracranial metastases were not evident. At the fourth craniotomy, bromodeoxyuridine (BrdU) was administered intravenously to label tumor cells in the S phase of the cell cycle. The BrdU-labeled cells accounted for 9.0{\%}; they are usually less than 1{\%} in benign meningiomas. Meningothelial meningiomas with a high labeling index recur rapidly, even after Simpson's grade 2 removal, and treatment for a malignant meningioma should be instituted.",
author = "T. Iwaki and I. Takeshita and M. Fukui and K. Kitamura",
year = "1987",
month = "9",
day = "1",
doi = "10.1007/BF00688188",
language = "English",
volume = "74",
pages = "243--247",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Cell kinetics of the malignant evolution of meningothelial meningioma

AU - Iwaki, T.

AU - Takeshita, I.

AU - Fukui, M.

AU - Kitamura, K.

PY - 1987/9/1

Y1 - 1987/9/1

N2 - A meningotheliomatous meningioma occurred in the right parietal parasagittal region of a 43-year-old woman. A total excision was carried out. Three years and 9 months later, one parasagittal and two falx tumours in close proximity recurred and were excised. The falx tumors showed the features of an anaplastic transitional meningioma with increased mitoses. The falx meningioma recurred locally and repeatedly, despite radiation therapy and chemoimmunotherapy. She died 7 years and 8 months after the onset. At autopsy, the tumor was found to have metastasized via the cerebrospinal fluid to the spinal cord and pituitary stalk. Extracranial metastases were not evident. At the fourth craniotomy, bromodeoxyuridine (BrdU) was administered intravenously to label tumor cells in the S phase of the cell cycle. The BrdU-labeled cells accounted for 9.0%; they are usually less than 1% in benign meningiomas. Meningothelial meningiomas with a high labeling index recur rapidly, even after Simpson's grade 2 removal, and treatment for a malignant meningioma should be instituted.

AB - A meningotheliomatous meningioma occurred in the right parietal parasagittal region of a 43-year-old woman. A total excision was carried out. Three years and 9 months later, one parasagittal and two falx tumours in close proximity recurred and were excised. The falx tumors showed the features of an anaplastic transitional meningioma with increased mitoses. The falx meningioma recurred locally and repeatedly, despite radiation therapy and chemoimmunotherapy. She died 7 years and 8 months after the onset. At autopsy, the tumor was found to have metastasized via the cerebrospinal fluid to the spinal cord and pituitary stalk. Extracranial metastases were not evident. At the fourth craniotomy, bromodeoxyuridine (BrdU) was administered intravenously to label tumor cells in the S phase of the cell cycle. The BrdU-labeled cells accounted for 9.0%; they are usually less than 1% in benign meningiomas. Meningothelial meningiomas with a high labeling index recur rapidly, even after Simpson's grade 2 removal, and treatment for a malignant meningioma should be instituted.

UR - http://www.scopus.com/inward/record.url?scp=0023205810&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023205810&partnerID=8YFLogxK

U2 - 10.1007/BF00688188

DO - 10.1007/BF00688188

M3 - Article

C2 - 3673517

AN - SCOPUS:0023205810

VL - 74

SP - 243

EP - 247

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 3

ER -