Cell-to-cell infection by HIV contributes over half of virus infection

Shingo Iwami, Junko S. Takeuchi, Shinji Nakaoka, Fabrizio Mammano, François Clavel, Hisashi Inaba, Tomoko Kobayashi, Naoko Misawa, Kazuyuki Aihara, Yoshio Koyanagi, Kei Sato

研究成果: ジャーナルへの寄稿記事

42 引用 (Scopus)

抄録

Cell-to-cell viral infection, in which viruses spread through contact of infected cell with surrounding uninfected cells, has been considered as a critical mode of virus infection. However, since it is technically difficult to experimentally discriminate the two modes of viral infection, namely cell-free infection and cell-to-cell infection, the quantitative information that underlies cell-to-cell infection has yet to be elucidated, and its impact on virus spread remains unclear. To address this fundamental question in virology, we quantitatively analyzed the dynamics of cell-to-cell and cell-free human immunodeficiency virus type 1 (HIV-1) infections through experimental-mathematical investigation. Our analyses demonstrated that the cell-to-cell infection mode accounts for approximately 60% of viral infection, and this infection mode shortens the generation time of viruses by 0.9 times and increases the viral fitness by 3.9 times. Our results suggest that even a complete block of the cell-free infection would provide only a limited impact on HIV-1 spread.

元の言語英語
記事番号e08150
ジャーナルeLife
4
発行部数OCTOBER2015
DOI
出版物ステータス出版済み - 10 6 2015

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Virus Diseases
Viruses
HIV Infections
Infection
HIV-1
Virology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

これを引用

Iwami, S., Takeuchi, J. S., Nakaoka, S., Mammano, F., Clavel, F., Inaba, H., ... Sato, K. (2015). Cell-to-cell infection by HIV contributes over half of virus infection. eLife, 4(OCTOBER2015), [e08150]. https://doi.org/10.7554/eLife.08150

Cell-to-cell infection by HIV contributes over half of virus infection. / Iwami, Shingo; Takeuchi, Junko S.; Nakaoka, Shinji; Mammano, Fabrizio; Clavel, François; Inaba, Hisashi; Kobayashi, Tomoko; Misawa, Naoko; Aihara, Kazuyuki; Koyanagi, Yoshio; Sato, Kei.

:: eLife, 巻 4, 番号 OCTOBER2015, e08150, 06.10.2015.

研究成果: ジャーナルへの寄稿記事

Iwami, S, Takeuchi, JS, Nakaoka, S, Mammano, F, Clavel, F, Inaba, H, Kobayashi, T, Misawa, N, Aihara, K, Koyanagi, Y & Sato, K 2015, 'Cell-to-cell infection by HIV contributes over half of virus infection', eLife, 巻. 4, 番号 OCTOBER2015, e08150. https://doi.org/10.7554/eLife.08150
Iwami S, Takeuchi JS, Nakaoka S, Mammano F, Clavel F, Inaba H その他. Cell-to-cell infection by HIV contributes over half of virus infection. eLife. 2015 10 6;4(OCTOBER2015). e08150. https://doi.org/10.7554/eLife.08150
Iwami, Shingo ; Takeuchi, Junko S. ; Nakaoka, Shinji ; Mammano, Fabrizio ; Clavel, François ; Inaba, Hisashi ; Kobayashi, Tomoko ; Misawa, Naoko ; Aihara, Kazuyuki ; Koyanagi, Yoshio ; Sato, Kei. / Cell-to-cell infection by HIV contributes over half of virus infection. :: eLife. 2015 ; 巻 4, 番号 OCTOBER2015.
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