抄録
Cell-to-cell viral infection, in which viruses spread through contact of infected cell with surrounding uninfected cells, has been considered as a critical mode of virus infection. However, since it is technically difficult to experimentally discriminate the two modes of viral infection, namely cell-free infection and cell-to-cell infection, the quantitative information that underlies cell-to-cell infection has yet to be elucidated, and its impact on virus spread remains unclear. To address this fundamental question in virology, we quantitatively analyzed the dynamics of cell-to-cell and cell-free human immunodeficiency virus type 1 (HIV-1) infections through experimental-mathematical investigation. Our analyses demonstrated that the cell-to-cell infection mode accounts for approximately 60% of viral infection, and this infection mode shortens the generation time of viruses by 0.9 times and increases the viral fitness by 3.9 times. Our results suggest that even a complete block of the cell-free infection would provide only a limited impact on HIV-1 spread.
| 元の言語 | 英語 |
|---|---|
| 記事番号 | e08150 |
| ジャーナル | eLife |
| 巻 | 4 |
| 発行部数 | OCTOBER2015 |
| DOI | |
| 出版物ステータス | 出版済み - 10 6 2015 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
これを引用
Cell-to-cell infection by HIV contributes over half of virus infection. / Iwami, Shingo; Takeuchi, Junko S.; Nakaoka, Shinji; Mammano, Fabrizio; Clavel, François; Inaba, Hisashi; Kobayashi, Tomoko; Misawa, Naoko; Aihara, Kazuyuki; Koyanagi, Yoshio; Sato, Kei.
：: eLife, 巻 4, 番号 OCTOBER2015, e08150, 06.10.2015.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Cell-to-cell infection by HIV contributes over half of virus infection
AU - Iwami, Shingo
AU - Takeuchi, Junko S.
AU - Nakaoka, Shinji
AU - Mammano, Fabrizio
AU - Clavel, François
AU - Inaba, Hisashi
AU - Kobayashi, Tomoko
AU - Misawa, Naoko
AU - Aihara, Kazuyuki
AU - Koyanagi, Yoshio
AU - Sato, Kei
PY - 2015/10/6
Y1 - 2015/10/6
N2 - Cell-to-cell viral infection, in which viruses spread through contact of infected cell with surrounding uninfected cells, has been considered as a critical mode of virus infection. However, since it is technically difficult to experimentally discriminate the two modes of viral infection, namely cell-free infection and cell-to-cell infection, the quantitative information that underlies cell-to-cell infection has yet to be elucidated, and its impact on virus spread remains unclear. To address this fundamental question in virology, we quantitatively analyzed the dynamics of cell-to-cell and cell-free human immunodeficiency virus type 1 (HIV-1) infections through experimental-mathematical investigation. Our analyses demonstrated that the cell-to-cell infection mode accounts for approximately 60% of viral infection, and this infection mode shortens the generation time of viruses by 0.9 times and increases the viral fitness by 3.9 times. Our results suggest that even a complete block of the cell-free infection would provide only a limited impact on HIV-1 spread.
AB - Cell-to-cell viral infection, in which viruses spread through contact of infected cell with surrounding uninfected cells, has been considered as a critical mode of virus infection. However, since it is technically difficult to experimentally discriminate the two modes of viral infection, namely cell-free infection and cell-to-cell infection, the quantitative information that underlies cell-to-cell infection has yet to be elucidated, and its impact on virus spread remains unclear. To address this fundamental question in virology, we quantitatively analyzed the dynamics of cell-to-cell and cell-free human immunodeficiency virus type 1 (HIV-1) infections through experimental-mathematical investigation. Our analyses demonstrated that the cell-to-cell infection mode accounts for approximately 60% of viral infection, and this infection mode shortens the generation time of viruses by 0.9 times and increases the viral fitness by 3.9 times. Our results suggest that even a complete block of the cell-free infection would provide only a limited impact on HIV-1 spread.
UR - http://www.scopus.com/inward/record.url?scp=84946606539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946606539&partnerID=8YFLogxK
U2 - 10.7554/eLife.08150
DO - 10.7554/eLife.08150
M3 - Article
C2 - 26441404
AN - SCOPUS:84946606539
VL - 4
JO - eLife
JF - eLife
SN - 2050-084X
IS - OCTOBER2015
M1 - e08150
ER -