Cellular behaviors on polymeric scaffolds with 2D-patterned mechanical properties

Shinichiro Shimomura, Hisao Matsuno, Yohei Kinoshita, Satoshi Fujimura, Keiji Tanaka

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

We propose a novel concept for cellular scaffolds with 2D-patterned mechanical properties. Thin films of glassy polystyrene (PS) with thicknesses ranging from 100 nm to 1 μm were prepared on epoxy resin-based line and space (L&S) patterned substrates. Although the outermost surface of PS on the L- and S-regions was sufficiently flat at the same level, the mechanical responses differed depending on the presence of the underlying resin foundation. The initial cell adhesion and spreading and the proliferation on the scaffolds were affected by the 2D-patterned mechanical properties, that is, cellular behavior was suppressed on mechanically unstable S-regions.

元の言語英語
ページ(範囲)737-743
ページ数7
ジャーナルPolymer Journal
50
発行部数8
DOI
出版物ステータス出版済み - 8 1 2018

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Polystyrenes
Scaffolds
Epoxy Resins
Mechanical properties
Cell adhesion
Epoxy resins
Resins
Thin films
Substrates

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Materials Chemistry

これを引用

Cellular behaviors on polymeric scaffolds with 2D-patterned mechanical properties. / Shimomura, Shinichiro; Matsuno, Hisao; Kinoshita, Yohei; Fujimura, Satoshi; Tanaka, Keiji.

:: Polymer Journal, 巻 50, 番号 8, 01.08.2018, p. 737-743.

研究成果: ジャーナルへの寄稿記事

Shimomura, Shinichiro ; Matsuno, Hisao ; Kinoshita, Yohei ; Fujimura, Satoshi ; Tanaka, Keiji. / Cellular behaviors on polymeric scaffolds with 2D-patterned mechanical properties. :: Polymer Journal. 2018 ; 巻 50, 番号 8. pp. 737-743.
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