Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks

Tomoyuki Koutoku, Hirokazu Takahashi, Shozo Tomonaga, Daichi Oikawa, Shin Saito, Tetsuya Tachibana, Li Han, Kohsuke Hayamizu, D. Michael Denbow, Mitsuhiro Furuse

研究成果: ジャーナルへの寄稿学術誌査読

52 被引用数 (Scopus)


The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or l-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. l-Serine similarly decreased isolation-induced vocalizations and spontaneous activity. To clarify the mechanism by which central PS attenuates isolation-induced stress behavior, the contribution of the acetylcholine (ACh) receptor (AChR) was also investigated. PS was co-injected i.c.v. with the muscarinic AChR (M-AChR) antagonist scopolamine or the nicotinic AChR (N-AChR) antagonist hexamethonium. The suppression of vocalizations and spontaneous activity by PS was partially attenuated by scopolamine, but not hexamethonium. These findings indicate that isolation-induced stress behavior are attenuated by PS, acting partially through the M-AChR.

ジャーナルNeurochemistry International
出版ステータス出版済み - 8月 2005

!!!All Science Journal Classification (ASJC) codes

  • 細胞および分子神経科学
  • 細胞生物学


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