Central administration of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide differentially regulates energy metabolism in chicks

Tetsuya Tachibana, Daichi Oikawa, Nami Adachi, Tim Boswell, Mitsuhiro Furuse

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are the members of the glucagon superfamily and bind to common receptors while PACAP also acts via the PACAP-specific receptor, PAC1. The aim of the present study was to investigate whether intracerebroventricular (ICV) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick. ICV injection of VIP did not significantly affect rectal temperature, but decreased energy expenditure. On the other hand, ICV injection of PACAP significantly increased both body temperature and energy expenditure. These specific actions of PACAP could be explained by an interaction with the PAC1 receptor, since they were partly, but not entirely, attenuated by PACAP (6-38), a PAC1 receptor antagonist. In addition, it was observed that central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations. This suggests that both peptides act centrally to regulate a catabolic response. In summary, brain VIP and PACAP both appear to exert generally catabolic effects on energy metabolism in the chick, but their influence on body temperature and glucose metabolism differs and their central effects do not appear to be mediated by the same receptors.

元の言語英語
ページ(範囲)156-164
ページ数9
ジャーナルComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
147
発行部数1
DOI
出版物ステータス出版済み - 5 1 2007

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
Vasoactive Intestinal Peptide
Energy Metabolism
Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
Body Temperature
Injections
Temperature
Glucagon
Metabolism
Fatty Acids
Brain
Glucose
Peptides
Plasmas

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

これを引用

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abstract = "Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are the members of the glucagon superfamily and bind to common receptors while PACAP also acts via the PACAP-specific receptor, PAC1. The aim of the present study was to investigate whether intracerebroventricular (ICV) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick. ICV injection of VIP did not significantly affect rectal temperature, but decreased energy expenditure. On the other hand, ICV injection of PACAP significantly increased both body temperature and energy expenditure. These specific actions of PACAP could be explained by an interaction with the PAC1 receptor, since they were partly, but not entirely, attenuated by PACAP (6-38), a PAC1 receptor antagonist. In addition, it was observed that central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations. This suggests that both peptides act centrally to regulate a catabolic response. In summary, brain VIP and PACAP both appear to exert generally catabolic effects on energy metabolism in the chick, but their influence on body temperature and glucose metabolism differs and their central effects do not appear to be mediated by the same receptors.",
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T1 - Central administration of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide differentially regulates energy metabolism in chicks

AU - Tachibana, Tetsuya

AU - Oikawa, Daichi

AU - Adachi, Nami

AU - Boswell, Tim

AU - Furuse, Mitsuhiro

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AB - Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are the members of the glucagon superfamily and bind to common receptors while PACAP also acts via the PACAP-specific receptor, PAC1. The aim of the present study was to investigate whether intracerebroventricular (ICV) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick. ICV injection of VIP did not significantly affect rectal temperature, but decreased energy expenditure. On the other hand, ICV injection of PACAP significantly increased both body temperature and energy expenditure. These specific actions of PACAP could be explained by an interaction with the PAC1 receptor, since they were partly, but not entirely, attenuated by PACAP (6-38), a PAC1 receptor antagonist. In addition, it was observed that central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations. This suggests that both peptides act centrally to regulate a catabolic response. In summary, brain VIP and PACAP both appear to exert generally catabolic effects on energy metabolism in the chick, but their influence on body temperature and glucose metabolism differs and their central effects do not appear to be mediated by the same receptors.

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