Central adrenomedullin augments the baroreceptor reflex in conscious rabbits

Kiyoshi Matsumura, Isao Abe, Takuya Tsuchihashi, Masatoshi Fujishima

研究成果: Contribution to journalArticle

22 被引用数 (Scopus)

抄録

We examined the roles of central adrenomedullin, proadrenomedullin N- terminal 20 peptide (PAMP), and calcitonin gene-related peptide (CGRP) on the baroreceptor reflex in conscious rabbits. Intracerebroventricular injection of adrenomedullin (0.2 and 1 nmol/80 μL) elicited dose-related increases in arterial pressure and renal sympathetic nerve activity. On the other hand, a subpressor dose of intracerebroventricular infusion of adrenomedullin (1 nmol/300 μL per hour) caused significant increases in baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G(max); -14.9±1.7 versus -8.0±0.7%/mm Hg, P<0.01, and -8.1±0.8 versus -5.1±0.5 bpm/mm Hg, P<0.01, respectively). Intracerebroventricular infusion of CGRP (1 nmol/300 μL per hour), which is structurally homologous to adrenomedullin, also enhanced the baroreflex controls of renal sympathetic nerve activity and heart rate. However, the intracerebroventricular infusion of PAMP (30 nmol/300 μL per hour) failed to alter the baseline levels of arterial pressure and baroreflex sensitivities. These results suggest that central adrenomedullin and CGRP, but not PAMP, participate in cardiovascular regulation to augment the baroreflex controls of renal sympathetic nerve activity and heart rate in conscious rabbits.

本文言語英語
ページ(範囲)992-997
ページ数6
ジャーナルHypertension
33
4
DOI
出版ステータス出版済み - 4 1999

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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