Central cardiovascular action of neuropeptide Y in conscious rabbits

Kiyoshi Matsumura, Takuya Tsuchihashi, Isao Abe

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

抄録

We determined the central interactions of neuropeptide Y and leptin on cardiovascular and sympathetic responses in conscious rabbits. Intracerebroventricular injections of neuropeptide Y (0.1 and 1 nmol/40 μL) elicited dose-related decreases in arterial pressure and renal sympathetic nerve activity without a significant change in heart rate. Peak depressor or sympathoinhibitory responses of mean arterial pressure and renal sympathetic nerve activity (-13.0±1.5 mm Hg and -27.6±4.9%) were observed at 25 and 20 minutes after intracerebroventricular injection of 1 nmol of neuropeptide Y, respectively. Pretreatment with intracerebroventricular injection of leptin (3 nmol) prevented the depressor and sympathoinhibitory responses elicited by intracerebroventricular neuropeptide Y. Intravenous injection of the same dose of neuropeptide Y (1 nmol) as that used in the intracerebroventricular experiment failed to cause any cardiovascular and renal sympathetic nerve responses. On the other hand, a subdepressor dose of intracerebroventricular infusion of neuropeptide Y (1 nmol/300 μL per hour) significantly attenuated the baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G(max); -7.4±0.7 versus -13.7±0.9%/mm Hg, P<0.01, and -4.0±0.3 versus -6.7±0.8 bpm/mm Hg, P<0.05, respectively). These results suggest that central neuropeptide Y participates in the regulations of the sympathetic nerve activity to kidney and the baroreceptor reflex and that the depressor response induced by intracerebroventricular neuropeptide Y is modulated, at least in part, by central leptin in conscious rabbits.

元の言語英語
ページ(範囲)1040-1044
ページ数5
ジャーナルHypertension
36
発行部数6
DOI
出版物ステータス出版済み - 1 1 2000

Fingerprint

Neuropeptide Y
Rabbits
Kidney
Leptin
Baroreflex
Injections
Arterial Pressure
Heart Rate
Intraventricular Infusions
Intravenous Injections

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Central cardiovascular action of neuropeptide Y in conscious rabbits. / Matsumura, Kiyoshi; Tsuchihashi, Takuya; Abe, Isao.

:: Hypertension, 巻 36, 番号 6, 01.01.2000, p. 1040-1044.

研究成果: ジャーナルへの寄稿記事

Matsumura, K, Tsuchihashi, T & Abe, I 2000, 'Central cardiovascular action of neuropeptide Y in conscious rabbits', Hypertension, 巻. 36, 番号 6, pp. 1040-1044. https://doi.org/10.1161/01.HYP.36.6.1040
Matsumura, Kiyoshi ; Tsuchihashi, Takuya ; Abe, Isao. / Central cardiovascular action of neuropeptide Y in conscious rabbits. :: Hypertension. 2000 ; 巻 36, 番号 6. pp. 1040-1044.
@article{5cebba2f27374dc7939df11598c340ca,
title = "Central cardiovascular action of neuropeptide Y in conscious rabbits",
abstract = "We determined the central interactions of neuropeptide Y and leptin on cardiovascular and sympathetic responses in conscious rabbits. Intracerebroventricular injections of neuropeptide Y (0.1 and 1 nmol/40 μL) elicited dose-related decreases in arterial pressure and renal sympathetic nerve activity without a significant change in heart rate. Peak depressor or sympathoinhibitory responses of mean arterial pressure and renal sympathetic nerve activity (-13.0±1.5 mm Hg and -27.6±4.9{\%}) were observed at 25 and 20 minutes after intracerebroventricular injection of 1 nmol of neuropeptide Y, respectively. Pretreatment with intracerebroventricular injection of leptin (3 nmol) prevented the depressor and sympathoinhibitory responses elicited by intracerebroventricular neuropeptide Y. Intravenous injection of the same dose of neuropeptide Y (1 nmol) as that used in the intracerebroventricular experiment failed to cause any cardiovascular and renal sympathetic nerve responses. On the other hand, a subdepressor dose of intracerebroventricular infusion of neuropeptide Y (1 nmol/300 μL per hour) significantly attenuated the baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G(max); -7.4±0.7 versus -13.7±0.9{\%}/mm Hg, P<0.01, and -4.0±0.3 versus -6.7±0.8 bpm/mm Hg, P<0.05, respectively). These results suggest that central neuropeptide Y participates in the regulations of the sympathetic nerve activity to kidney and the baroreceptor reflex and that the depressor response induced by intracerebroventricular neuropeptide Y is modulated, at least in part, by central leptin in conscious rabbits.",
author = "Kiyoshi Matsumura and Takuya Tsuchihashi and Isao Abe",
year = "2000",
month = "1",
day = "1",
doi = "10.1161/01.HYP.36.6.1040",
language = "English",
volume = "36",
pages = "1040--1044",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Central cardiovascular action of neuropeptide Y in conscious rabbits

AU - Matsumura, Kiyoshi

AU - Tsuchihashi, Takuya

AU - Abe, Isao

PY - 2000/1/1

Y1 - 2000/1/1

N2 - We determined the central interactions of neuropeptide Y and leptin on cardiovascular and sympathetic responses in conscious rabbits. Intracerebroventricular injections of neuropeptide Y (0.1 and 1 nmol/40 μL) elicited dose-related decreases in arterial pressure and renal sympathetic nerve activity without a significant change in heart rate. Peak depressor or sympathoinhibitory responses of mean arterial pressure and renal sympathetic nerve activity (-13.0±1.5 mm Hg and -27.6±4.9%) were observed at 25 and 20 minutes after intracerebroventricular injection of 1 nmol of neuropeptide Y, respectively. Pretreatment with intracerebroventricular injection of leptin (3 nmol) prevented the depressor and sympathoinhibitory responses elicited by intracerebroventricular neuropeptide Y. Intravenous injection of the same dose of neuropeptide Y (1 nmol) as that used in the intracerebroventricular experiment failed to cause any cardiovascular and renal sympathetic nerve responses. On the other hand, a subdepressor dose of intracerebroventricular infusion of neuropeptide Y (1 nmol/300 μL per hour) significantly attenuated the baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G(max); -7.4±0.7 versus -13.7±0.9%/mm Hg, P<0.01, and -4.0±0.3 versus -6.7±0.8 bpm/mm Hg, P<0.05, respectively). These results suggest that central neuropeptide Y participates in the regulations of the sympathetic nerve activity to kidney and the baroreceptor reflex and that the depressor response induced by intracerebroventricular neuropeptide Y is modulated, at least in part, by central leptin in conscious rabbits.

AB - We determined the central interactions of neuropeptide Y and leptin on cardiovascular and sympathetic responses in conscious rabbits. Intracerebroventricular injections of neuropeptide Y (0.1 and 1 nmol/40 μL) elicited dose-related decreases in arterial pressure and renal sympathetic nerve activity without a significant change in heart rate. Peak depressor or sympathoinhibitory responses of mean arterial pressure and renal sympathetic nerve activity (-13.0±1.5 mm Hg and -27.6±4.9%) were observed at 25 and 20 minutes after intracerebroventricular injection of 1 nmol of neuropeptide Y, respectively. Pretreatment with intracerebroventricular injection of leptin (3 nmol) prevented the depressor and sympathoinhibitory responses elicited by intracerebroventricular neuropeptide Y. Intravenous injection of the same dose of neuropeptide Y (1 nmol) as that used in the intracerebroventricular experiment failed to cause any cardiovascular and renal sympathetic nerve responses. On the other hand, a subdepressor dose of intracerebroventricular infusion of neuropeptide Y (1 nmol/300 μL per hour) significantly attenuated the baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G(max); -7.4±0.7 versus -13.7±0.9%/mm Hg, P<0.01, and -4.0±0.3 versus -6.7±0.8 bpm/mm Hg, P<0.05, respectively). These results suggest that central neuropeptide Y participates in the regulations of the sympathetic nerve activity to kidney and the baroreceptor reflex and that the depressor response induced by intracerebroventricular neuropeptide Y is modulated, at least in part, by central leptin in conscious rabbits.

UR - http://www.scopus.com/inward/record.url?scp=0033664890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033664890&partnerID=8YFLogxK

U2 - 10.1161/01.HYP.36.6.1040

DO - 10.1161/01.HYP.36.6.1040

M3 - Article

C2 - 11116122

AN - SCOPUS:0033664890

VL - 36

SP - 1040

EP - 1044

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 6

ER -