Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits

Kiyoshi Matsumura, Isao Abe, Takuya Tsuchihashi, Masatoshi Fujishima

研究成果: Contribution to journalArticle査読

78 被引用数 (Scopus)

抄録

We determined the cardiovascular and neurohormonal responses to intracerebroventricular injection of leptin in conscious rabbits. Intracerebroventricular injection of leptin elicited dose-related increases in mean arterial pressure and renal sympathetic nerve activity while producing no consistent, significant increases in heart rate. Peak values of mean arterial pressure and renal sympathetic nerve activity induced by intracerebroventricular injection of 50 μg of leptin (+17.3 ± 1.2 mmHg and +47.9 ± 12.0%) were obtained at 10 and 20 min after injection, respectively. Plasma catecholamine concentrations significantly increased at 60 rain after intracerebroventricular injection of leptin (control vs. 60 min; epinephrine: 33 + 12 vs. 97 ± 27 pg/ml, P < 0.05; norepinephrine: 298 ± 39 vs. 503 + 86 pg/ml, P < 0.05). Intracerebroventricular injection of leptin also caused significant increases in plasma vasopressin and glucose levels. However, pretreatment with intravenous injection of pentolinium (5 mg/kg), a ganglion blocking agent, abolished these cardiovascular and neurohormonal responses. On the other hand, intravenous injection of the same dose of leptin (50 μg) as used in the intracerebroventricular experiment failed to cause any cardiovascular and renal sympathetic nerve responses. These results suggest that intracerebroventricular leptin acts in the central nervous system and activates sympathoadrenal outflow, resulting in increases in arterial pressure and plasma glucose levels in conscious rabbits.

本文言語英語
ページ(範囲)R1314-R1320
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
278
5 47-5
DOI
出版ステータス出版済み - 2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生理学
  • 生理学(医学)

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