Cepharanthine inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing expression of vascular endothelial growth factor and interleukin-8

Koji Harada, Tarannum Ferdous, Yasutaka Itashiki, Michiyo Takii, Takamichi Mano, Yoshihide Mori, Yoshiya Ueyama

研究成果: Contribution to journalArticle査読

24 被引用数 (Scopus)

抄録

Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, which is widely used for the treatment of many acute and chronic diseases, and can exert antitumor effects on several human cancer cell lines. However, little is known about the detailed mechanisms of the antitumor activity of Cepharanthine. In the present study, we determined whether Cepharanthine could suppress angiogenesis and growth of human oral squamous cell carcinoma (OSCC) cells in vitro and in vivo. Cepharanthine significantly inhibited expression of two major pro-angiogenic molecules, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8), in cultured cells and in cells implanted into the subcutaneous tissue of nude mice. Also, Cepharanthine inhibited the nuclear factor-κB (NF-κB) activity in human OSCC cells in vitro and in vivo. The decreased expression of VEGF and IL-8 correlated with decreased tumor cell growth and decreased vascularization in vitro and in vivo. These findings suggest that Cepharanthine can suppress angiogenesis and growth of OSCC cells by inhibiting expression of VEGF and IL-8 involved in the blockade of NF-κB activity.

本文言語英語
ページ(範囲)1025-1035
ページ数11
ジャーナルInternational journal of oncology
35
5
DOI
出版ステータス出版済み - 11 1 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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