Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space

Motohiro Tani, Makoto Ito, Yasuyuki Igarashi

研究成果: Contribution to journalReview article査読

111 被引用数 (Scopus)

抄録

Sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, have emerged as a new class of lipid biomodulators of various cell functions. These metabolites are known to function not only as intracellular second messengers, but also in the extracellular space. Sphingosine 1-phosphate especially has numerous functions as an important extracellular mediator that binds to cell surface S1P receptors. Recent studies have also shown that sphingolipid-metabolizing enzymes function not only in intracellular organelles but also in the extracellular spaces, including the outer leaflet of the plasma membrane. This review focuses on the metabolic enzymes (acid and alkaline sphingomyelinases, neutral ceramidase, and sphingosine kinase) that are involved in the production of the sphingolipid metabolites in these extracellular spaces, and on the metabolic pathway itself.

本文言語英語
ページ(範囲)229-237
ページ数9
ジャーナルCellular Signalling
19
2
DOI
出版ステータス出版済み - 2 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • Cell Biology

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