Cerebrospinal fluid concentrations of interleukin-1β, tumour necrosis factor-α, and interferon gamma in bacterial meningitis

S. Ohga, T. Aoki, K. Okada, H. Akeda, K. Fujioka, A. Ohshima, T. Mori, I. Minamishima, K. Ueda

研究成果: Contribution to journalArticle査読

77 被引用数 (Scopus)

抄録

To investigate the role of the inflammatory cytokines, the cerebrospinal fluid concentrations of interleukin (IL)-1β, tumour necrosis factor-α (TNF-α), and interferon gamma (IFN-γ) were measured in 11 children with bacterial meningitis and two with mycoplasmic meningoencephalitis and compared with those in 50 children with aseptic meningitis and 15 with non-pleocytotic cerebrospinal fluid. Concentrations of IL-1β and TNF-α were each significantly higher in the cerebrospinal fluid of patients with bacterial meningitis than in those with aseptic meningitis or those with non-pleocytotic cerebrospinal fluid. IFN-γ was detected at low concentrations in the cerebrospinal fluid of only 2/11 of those with bacterial meningitis. On the other hand, the IFN-γ concentration was the highest in the cerebrospinal fluid of patients with aseptic meningitis. These results suggest that the inflammatory cytokines are differently released in the intrathecal space infected with viruses or bacteria.

本文言語英語
ページ(範囲)123-125
ページ数3
ジャーナルArchives of Disease in Childhood
70
2
DOI
出版ステータス出版済み - 1994

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康

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