Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis

研究成果: ジャーナルへの寄稿記事

抄録

Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid cytokine profile of HP by measuring 28 cytokines/chemokines/growth factors with a multiplexed fluorescent immunoassay in 8 patients with HP (6 idiopathic, 1 IgG4-related, 1 anti-neutrophil cytoplasmic antibody-related), and 11 with other non-inflammatory neurologic diseases (OND). Interleukin (IL)-4, IL-5, IL-9, IL-10, TNF-α, and CXCL8/IL-8 levels were significantly higher in idiopathic HP (IHP) than OND. Cluster analyses disclosed two major clusters: one mainly consisted of IHP and the other of OND, suggesting a unique cytokine profile in IHP.

元の言語英語
ページ(範囲)38-43
ページ数6
ジャーナルJournal of Neuroimmunology
330
DOI
出版物ステータス出版済み - 5 15 2019

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Nervous System Diseases
Meningitis
Chemokines
Cerebrospinal Fluid
Intercellular Signaling Peptides and Proteins
Cytokines
Interleukin-9
Dura Mater
Antineutrophil Cytoplasmic Antibodies
Interleukin-5
Rare Diseases
Interleukin-8
Immunoassay
Interleukin-4
Interleukin-10
Cluster Analysis
Immunoglobulin G
Brain

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

これを引用

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title = "Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis",
abstract = "Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid cytokine profile of HP by measuring 28 cytokines/chemokines/growth factors with a multiplexed fluorescent immunoassay in 8 patients with HP (6 idiopathic, 1 IgG4-related, 1 anti-neutrophil cytoplasmic antibody-related), and 11 with other non-inflammatory neurologic diseases (OND). Interleukin (IL)-4, IL-5, IL-9, IL-10, TNF-α, and CXCL8/IL-8 levels were significantly higher in idiopathic HP (IHP) than OND. Cluster analyses disclosed two major clusters: one mainly consisted of IHP and the other of OND, suggesting a unique cytokine profile in IHP.",
author = "Xu Zhang and Takayuki Fujii and Hidenori Ogata and Ryo Yamasaki and Katsuhisa Masaki and Yiwen Cui and Takuya Matsushita and Noriko Isobe and Jun-Ichi Kira",
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AU - Zhang, Xu

AU - Fujii, Takayuki

AU - Ogata, Hidenori

AU - Yamasaki, Ryo

AU - Masaki, Katsuhisa

AU - Cui, Yiwen

AU - Matsushita, Takuya

AU - Isobe, Noriko

AU - Kira, Jun-Ichi

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AB - Hypertrophic pachymeningitis (HP) is a rare neurologic disease causing inflammatory fibrous thickening of the brain and spinal dura mater. We investigated the cerebrospinal fluid cytokine profile of HP by measuring 28 cytokines/chemokines/growth factors with a multiplexed fluorescent immunoassay in 8 patients with HP (6 idiopathic, 1 IgG4-related, 1 anti-neutrophil cytoplasmic antibody-related), and 11 with other non-inflammatory neurologic diseases (OND). Interleukin (IL)-4, IL-5, IL-9, IL-10, TNF-α, and CXCL8/IL-8 levels were significantly higher in idiopathic HP (IHP) than OND. Cluster analyses disclosed two major clusters: one mainly consisted of IHP and the other of OND, suggesting a unique cytokine profile in IHP.

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