Cerebrovascular responsiveness to hypercapnia in alzheimer's dementia and vascular dementia of the binswanger type

Yasuo Kuwabara, Yuichi Ichiya, Makoto Otsuka, Kouji Masuda, Atsushi Ichimiya, Masatoshi Fujishima

    研究成果: Contribution to journalArticle査読

    43 被引用数 (Scopus)

    抄録

    Background and Purpose: Alzheimer's dementia is thought to be a primary degenerative dementia, whereas vascular dementia of the Binswanger type is an entity of vascular dementia. We evaluated the cerebrovascular responsiveness to hypercapnia to clarify the differences in the cerebral hemodynamics between two groups of patients. The subjects were eight younger control subjects, five age-matched control subjects, five Alzheimer's patients, and five patients with vascular dementia of the Binswanger type. Summary of Report: In the resting state, the regional cerebral blood flow was low in both Alzheimer's dementia and vascular dementia of the Binswanger type. The responsiveness to hypercapnia was preserved in Alzheimer's dementia, whereas it was impaired in vascular dementia of the Binswanger type in the cerebral cortices and in the deep white matter. Conclusions: These results suggest that small vascular lesions exist in vascular dementia of the Binswanger type but not in Alzheimer's dementia, even though regional cerebral blood flow was thought to decrease by hypometabolism in both types of dementia.

    本文言語英語
    ページ(範囲)594-598
    ページ数5
    ジャーナルStroke
    23
    4
    DOI
    出版ステータス出版済み - 4 1992

    All Science Journal Classification (ASJC) codes

    • Clinical Neurology
    • Cardiology and Cardiovascular Medicine
    • Advanced and Specialised Nursing

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