Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex

Kazuko Etou, Toshihide Kuroki, Takeshi Kawahara, Yuji Yonezawa, Nobutada Tashiro, Hideyuki Uchimura

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

Phencyclidine (PCP; 5.0 mg/kg, IP) produced a greater increase in extracellular dopamine (DA) levels in the prefrontal cortex than in the striatum, while PCP increased the extracellular 5-hydroxytryptamine (serotonin; 5-HT) levels in the prefrontal cortex but not the striatum, as determined by in vivo microdialysis in awake, freely moving rats. The cholecystokinin (CCK)-related decapeptide ceruletide (120 and 400 μg/kg, IP), administered 60 min prior to PCP, significantly attenuated the PCP-induced increase in the extracellular levels of DA and 5-HT in the prefrontal cortex, but not in the striatum. These effects were reversed by PD 135,158, a selective CCK-B receptor antagonist (0.1 mg/kg, SC), administered 5 min prior to ceruletide. When administered alone, ceruletide (400 μg/kg, IP) significantly increased basal extracellular DA levels only in the prefrontal cortex. The selective N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (0.5 mg/kg, IP) also increased extracellular DA levels in the prefrontal cortex, but this effect was unaffected by ceruletide pretreatment. These results suggest that ceruletide may differentially modulate basal and PCP-induced release of DA and 5-HT in the prefrontal cortex. Copyright (C) 1998 Elsevier Science Inc.

本文言語英語
ページ(範囲)427-434
ページ数8
ジャーナルPharmacology Biochemistry and Behavior
61
4
DOI
出版ステータス出版済み - 12 1998

All Science Journal Classification (ASJC) codes

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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