Cetuximab for patients with metastatic colorectal cancer - From the result of recent clinical trials

研究成果: ジャーナルへの寄稿記事

抄録

Cetuximab is a monoclonal antibody that inhibits human epidermal growth factor receptor, and was approved for metastatic advanced colorectal cancer (mCRC) in 2008 in Japan. Evidences confirming the efficacy of cetuximab have been accumulated in western countries. As the first- and second-line therapy, cetuximab plus chemotherapy showed longer survival compared with chemotherapy alone. As a third-line chemotherapy, among various anti-cancer agents for mCRC, only cetuximab could exhibit survival benefits in monotherapy or combination therapy with irinotecan. Recent studies suggest that the status of KRAS mutation is a predictive marker in colorectal cancer patients treated with cetuximab, and these findings lead to personalized cancer treatment.

元の言語英語
ページ(範囲)782-786
ページ数5
ジャーナルJapanese Journal of Cancer and Chemotherapy
37
発行部数5
出版物ステータス出版済み - 2010

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Colorectal Neoplasms
Clinical Trials
irinotecan
Drug Therapy
Survival
Epidermal Growth Factor Receptor
Neoplasms
Japan
Therapeutics
Monoclonal Antibodies
Cetuximab
Mutation

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Oncology
  • Cancer Research

これを引用

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