CFD analysis of the flow structure in a monkey upper airway validated by PIV experiments

Nguyen Lu Phuong, Tran Van Quang, Nguyen Dang Khoa, Ji Woong Kim, Kazuhide Ito

研究成果: ジャーナルへの寄稿記事

抄録

Inhalation exposure to airborne contaminants has adverse effects on humans; however, related research is typically conducted using in vivo/in vitro tests on animals. Extrapolating the test results is complicated by anatomical and physiological differences between animals and humans and a lack of understanding of the transport mechanism inside their respective respiratory tracts. This study determined the detailed air-flow structure in the upper airway of a monkey. A steady computational fluid dynamics simulation, which was validated by previous particle image velocimetry measurements, was adopted for flow rates of 4 L/min and 10 L/min to analyze the flow structure from the nasal/oral cavities to the trachea region in a monkey airway model. The low Reynolds number type k–ε model provided a reasonably accurate prediction of the airflow in a monkey upper airway. Furthermore, it was confirmed that large velocity gradients were generated in the nasal vestibule and larynx regions, as well as increased turbulent air kinetic energy and wall sheer stress.

元の言語英語
記事番号103304
ジャーナルRespiratory Physiology and Neurobiology
271
DOI
出版物ステータス出版済み - 1 2020

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Haplorhini
Air
Inhalation Exposure
Rheology
Nasal Cavity
Hydrodynamics
Larynx
Trachea
Nose
Respiratory System
Mouth
Research
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

これを引用

CFD analysis of the flow structure in a monkey upper airway validated by PIV experiments. / Phuong, Nguyen Lu; Quang, Tran Van; Khoa, Nguyen Dang; Kim, Ji Woong; Ito, Kazuhide.

:: Respiratory Physiology and Neurobiology, 巻 271, 103304, 01.2020.

研究成果: ジャーナルへの寄稿記事

Phuong, Nguyen Lu ; Quang, Tran Van ; Khoa, Nguyen Dang ; Kim, Ji Woong ; Ito, Kazuhide. / CFD analysis of the flow structure in a monkey upper airway validated by PIV experiments. :: Respiratory Physiology and Neurobiology. 2020 ; 巻 271.
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