Challenges in management of epidemic keratoconjunctivitis with emerging recombinant human adenoviruses

Gabriel Gonzalez, Nobuyo Yawata, Koki Aoki, Nobuyoshi Kitaichi

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

抄録

Adenoviral epidemic keratoconjunctivitis (EKC) presents as severe conjunctival inflammations involving the cornea that can lead to the development of corneal opacities and blurred vision, which can persist for months. EKC is highly contagious and responsible for outbreaks worldwide, therefore accurate diagnosis and rapid containment are imperative. EKC is caused by a number of types within Human adenovirus species D (HAdV-D): 8, 37 and 64 (formerly known as 19a) and these types were considered the major causes of EKC for over fifty years. Nonetheless, recent improved molecular typing methodologies have identified recombinant HAdV-D types 53, 54 and 56, as newly emerging etiologic agents of EKC infections worldwide. EKC cases due to these recombinant types have potentially been underdiagnosed and underestimated as a source of new EKC outbreaks. Recombination events among circulating HAdV-D types represent a source of new infectious disease threats. Also, the growing number of adenoviral types enabled genomic and phenotypic comparisons to determine pathological properties related to EKC. This review covers the clinical features of EKC, current challenges in clinical practice and recent progress in EKC-related HAdV research, which focuses on the development of novel diagnostic and therapeutic approaches.

元の言語英語
ページ(範囲)1-9
ページ数9
ジャーナルJournal of Clinical Virology
112
DOI
出版物ステータス出版済み - 3 1 2019

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Keratoconjunctivitis
Human Adenoviruses
Disease Outbreaks
Corneal Opacity
Molecular Typing
Cornea
Genetic Recombination
Communicable Diseases

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

これを引用

Challenges in management of epidemic keratoconjunctivitis with emerging recombinant human adenoviruses. / Gonzalez, Gabriel; Yawata, Nobuyo; Aoki, Koki; Kitaichi, Nobuyoshi.

:: Journal of Clinical Virology, 巻 112, 01.03.2019, p. 1-9.

研究成果: ジャーナルへの寄稿評論記事

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