Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor

Takuro Niidome, Nobukatsu Chijiiwa, Toshihide Yamasaki, Ken-Ichi Yamada, Takeshi Mori, Tatsuya Naganuma, Hideo Utsumi, Kazuhiro Ichikawa, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

抄録

Dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through the substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the Overhauser-enhanced MRI (OMRI) signal from the radicals. This system could be the basis of a functional tumor-imaging technique by OMRI.

元の言語英語
ページ(範囲)999-1001
ページ数3
ジャーナルChemistry Letters
43
発行部数7
DOI
出版物ステータス出版済み - 1 1 2014

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Magnetic resonance imaging
Tumors
Peptide Hydrolases
Peptides
Lysine
Polymers
Imaging techniques
Substrates
nitroxyl

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor. / Niidome, Takuro; Chijiiwa, Nobukatsu; Yamasaki, Toshihide; Yamada, Ken-Ichi; Mori, Takeshi; Naganuma, Tatsuya; Utsumi, Hideo; Ichikawa, Kazuhiro; Katayama, Yoshiki.

:: Chemistry Letters, 巻 43, 番号 7, 01.01.2014, p. 999-1001.

研究成果: ジャーナルへの寄稿記事

Niidome, Takuro ; Chijiiwa, Nobukatsu ; Yamasaki, Toshihide ; Yamada, Ken-Ichi ; Mori, Takeshi ; Naganuma, Tatsuya ; Utsumi, Hideo ; Ichikawa, Kazuhiro ; Katayama, Yoshiki. / Change in overhauser effect-enhanced MRI signal in response to uPA highly expressing in tumor. :: Chemistry Letters. 2014 ; 巻 43, 番号 7. pp. 999-1001.
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