抄録
A study was performed on the metabolism of fenitrothion (FS) in tiger shrimp Penaeus japonicus at different larval stages to elucidate the cause of the remarkable increase in the toxicity of organophosphorothionates to the shrimp larvae with the progress of the stages. The shrimp larvae (zoea, mysis and postlarvae) were exposed to 0.5 ppb [14C]FS. After 1.5-12 h exposure, [14C]FS and its metabolites accumulated in the larvae were extracted with benzene and then with ethyl ether. The benzene-extracts were determined by TLC and the ethyl ether-extracts were subjected to an enzymatic analysis. Zoea and mysis showed very low FS metabolic activity, and most of the FS absorbed by the larvae was present as FS itself in their bodies. However, their FS metabolic activity increased abruptly with their growth and resulted in an increase in the amount of fenitrooxon which displays extremely high toxicity as compared with FS, accompanying the simultaneous increase in the FS detoxication activity such as demethylation, hydrolysis and conjugation. The occurrence of the remarkable increase in the toxicity of organophosphorothionates to tiger shrimp larvae with the progress of the stages is probably due to the increase in the oxidative desulfuration activity, beyond the effect of the detoxication activity.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 489-496 |
| ページ数 | 8 |
| ジャーナル | Nippon Suisan Gakkaishi |
| 巻 | 56 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 1990 |
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All Science Journal Classification (ASJC) codes
- Aquatic Science
これを引用
Changes in Metabolic Activity of Tiger Shrimp Larvae at Different Stages to Fenitrothion, An Organophosphorus Insecticide. / Kobayashi, Kunio; Rompas, Rizald Max; Maekawa, Takako; Imada, Nobuyoshi; Oshima, Yuji.
：: Nippon Suisan Gakkaishi, 巻 56, 番号 3, 01.01.1990, p. 489-496.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Changes in Metabolic Activity of Tiger Shrimp Larvae at Different Stages to Fenitrothion, An Organophosphorus Insecticide
AU - Kobayashi, Kunio
AU - Rompas, Rizald Max
AU - Maekawa, Takako
AU - Imada, Nobuyoshi
AU - Oshima, Yuji
PY - 1990/1/1
Y1 - 1990/1/1
N2 - A study was performed on the metabolism of fenitrothion (FS) in tiger shrimp Penaeus japonicus at different larval stages to elucidate the cause of the remarkable increase in the toxicity of organophosphorothionates to the shrimp larvae with the progress of the stages. The shrimp larvae (zoea, mysis and postlarvae) were exposed to 0.5 ppb [14C]FS. After 1.5-12 h exposure, [14C]FS and its metabolites accumulated in the larvae were extracted with benzene and then with ethyl ether. The benzene-extracts were determined by TLC and the ethyl ether-extracts were subjected to an enzymatic analysis. Zoea and mysis showed very low FS metabolic activity, and most of the FS absorbed by the larvae was present as FS itself in their bodies. However, their FS metabolic activity increased abruptly with their growth and resulted in an increase in the amount of fenitrooxon which displays extremely high toxicity as compared with FS, accompanying the simultaneous increase in the FS detoxication activity such as demethylation, hydrolysis and conjugation. The occurrence of the remarkable increase in the toxicity of organophosphorothionates to tiger shrimp larvae with the progress of the stages is probably due to the increase in the oxidative desulfuration activity, beyond the effect of the detoxication activity.
AB - A study was performed on the metabolism of fenitrothion (FS) in tiger shrimp Penaeus japonicus at different larval stages to elucidate the cause of the remarkable increase in the toxicity of organophosphorothionates to the shrimp larvae with the progress of the stages. The shrimp larvae (zoea, mysis and postlarvae) were exposed to 0.5 ppb [14C]FS. After 1.5-12 h exposure, [14C]FS and its metabolites accumulated in the larvae were extracted with benzene and then with ethyl ether. The benzene-extracts were determined by TLC and the ethyl ether-extracts were subjected to an enzymatic analysis. Zoea and mysis showed very low FS metabolic activity, and most of the FS absorbed by the larvae was present as FS itself in their bodies. However, their FS metabolic activity increased abruptly with their growth and resulted in an increase in the amount of fenitrooxon which displays extremely high toxicity as compared with FS, accompanying the simultaneous increase in the FS detoxication activity such as demethylation, hydrolysis and conjugation. The occurrence of the remarkable increase in the toxicity of organophosphorothionates to tiger shrimp larvae with the progress of the stages is probably due to the increase in the oxidative desulfuration activity, beyond the effect of the detoxication activity.
UR - http://www.scopus.com/inward/record.url?scp=85008072320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008072320&partnerID=8YFLogxK
U2 - 10.2331/suisan.56.489
DO - 10.2331/suisan.56.489
M3 - Article
VL - 56
SP - 489
EP - 496
JO - Nippon Suisan Gakkaishi
JF - Nippon Suisan Gakkaishi
SN - 0021-5392
IS - 3
ER -