Changes in oral and cognitive functions among older Japanese dental outpatients: A 2-year follow-up study

Shinsuke Mizutani, Rui Egashira, Masahiro Yamaguchi, Keiko Tamai, Mizuki Yoshida, Tomotaka Kato, Yojiro Umezaki, Hisae Aoki, Toru Naito

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)


BACKGROUND: The relationship between oral and cognitive functions among older people is highly debated.

OBJECTIVE: To examine whether oral functions are related to changes in the levels of mild cognitive impairment (MCI) biomarkers in older Japanese outpatients.

METHODS: This observational study included 52 outpatients aged ≥65 years who underwent dental examinations at the Fukuoka Dental College Hospital. The Mini-Mental State Examination (MMSE) was performed, and MCI blood biomarker levels were assessed at baseline and after 2 years. The present dental and periodontal conditions and the oral functions (tongue pressure and masticatory performance) were evaluated. Changes in parameters from baseline to follow-up were compared using the Wilcoxon signed-rank test, McNemar test, or chi-squared test. Associations among changes in the parameters were analyzed using Spearman's rank correlation coefficient.

RESULTS: The follow-up rate in this study was 67%. The masticatory performance was improved (P < 0.001), whereas gingival inflammation was decreased (P < 0.001) over the 2-year period. A significant increase in the MMSE score (P < 0.001) and a decrease in MCI risk (P < 0.001) were noted. The decrease in MCI risk was correlated with the increase in both masticatory performance (ρ = -0.34; P < 0.05) and MMSE score (ρ = -0.56; P < 0.01).

CONCLUSION: A decrease in MCI risk, as demonstrated by the levels of the blood biomarkers, was correlated with an increase in the masticatory performance in Japanese outpatients.

ジャーナルJournal of oral rehabilitation
出版ステータス印刷前の電子出版 - 7月 9 2021


「Changes in oral and cognitive functions among older Japanese dental outpatients: A 2-year follow-up study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。