Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Hiroshi Tateishi, Daiki Setoyama, Takahiro A. Kato, Dongchon Kang, Jun Matsushima, Kojiro Nogami, Seiji Mawatari, Ryohei Kojima, Yuka Fujii, Yuta Sakemura, Takumi Shiraishi, Yoshiomi Imamura, Toshihiko Maekawa, Toyoko Asami, Yoshito Mizoguchi, Akira Monji

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.

本文言語英語
論文番号114636
ジャーナルPsychiatry research
313
DOI
出版ステータス出版済み - 7月 2022

!!!All Science Journal Classification (ASJC) codes

  • 精神医学および精神衛生
  • 生物学的精神医学

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